Brian D Wakefield

US Patent:

7838543, Nov 23, 2010

Filed:

Dec 16, 2005

Appl. No.:

11/719576

Inventors:

James Peter Beck - Indianapolis IN, US
Brian David Wakefield - Skokie IL, US
Frederic Laurent Cordier - Alcobendas, ES
Esteban Dominguez-Manzanares - Alcobendas, ES
Kevin Matthew Gardinier - Fishers IN, US
Peter Michael Greenen - Indianapolis IN, US
Kenneth Allen Savin - Indianapolis IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A01N 43/78
A61K 31/425
C07D 417/00
C07D 277/60

US Classification:

514367, 548162, 548152

Abstract:

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar, L, R, q, X, R, R, R, and Rare as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

US Patent:

7902356, Mar 8, 2011

Filed:

Dec 16, 2005

Appl. No.:

11/721079

Inventors:

Albert Kudzovi Amegadzie - Indianapolis IN, US
James Peter Beck - Zionsville IN, US
Kevin Matthew Gardinier - Fishers IN, US
Erik James Hembre - Indianapolis IN, US
James Craig Ruble - Greenwood IN, US
Kenneth Allen Savin - Indianapolis IN, US
Brian David Wakefield - Skokie IL, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D 265/36
C07D 413/00
C07D 401/00
C07D 513/02

US Classification:

544105, 544128, 544362, 546114

Abstract:

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R, q, p, R, t, Ar, L, Rand Rare as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

US Patent:

7985745, Jul 26, 2011

Filed:

Sep 28, 2007

Appl. No.:

11/863925

Inventors:

Marlon D. Cowart - Round Lake Beach IL, US
Robert J. Altenbach - Chicago IL, US
Huaqing Liu - Buffalo Grove IL, US
Irene Drizin - Wadsworth IL, US
Neil Wishart - Jefferson MA, US
David J. Babinski - Dallas TX, US
Robert J. Gregg - Libertyville IL, US
Arthur A. Hancock - Libertyville IL, US
Timothy A. Esbenshade - Schaumburg IL, US
Gin C. Hsieh - Long Grove IL, US
Jorge D. Brioni - Vernon Hills IL, US
Marie P. Honore - Evanston IL, US
Lawrence A. Black - Libertyville IL, US
Chen Zhao - Libertyville IL, US
Brian D. Wakefield - Evanston IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/395
A61K 31/495
A61K 31/498
A61K 31/502
A61P 25/00
A61P 25/02
A61P 19/02

US Classification:

51421021, 51425214, 514267

Abstract:

This invention discloses a method of treating pain by administering histamine Hreceptor ligands and compositions comprising the same.

US Patent:

8153813, Apr 10, 2012

Filed:

Dec 17, 2008

Appl. No.:

12/337433

Inventors:

Lawrence A. Black - Libertyville IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Gregory A. Gfesser - Lindenhurst IL, US
Brian D. Wakefield - Vernon Hills IL, US
Robert J. Altenbach - Chicago IL, US
Huaqing Liu - Buffalo Grove IL, US
Chen Zhao - Libertyville IL, US
Gin C. Hsieh - Long Grove IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/454
A61K 31/4545
C07D 417/04
C07D 417/14

US Classification:

548162, 514367, 514321, 514374, 5142338, 51425206, 514318, 544135, 544333, 544238, 546193, 546198

Abstract:

Compounds of formula (I).

US Patent:

8268846, Sep 18, 2012

Filed:

Jul 10, 2009

Appl. No.:

12/501137

Inventors:

Brian D. Wakefield - Vernon Hills IL, US
Robert J. Altenbach - Chicago IL, US
Lawrence A. Black - Libertyville IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Irene Drizin - Wadsworth IL, US
Huaqing Liu - Buffalo Grove IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 487/04
A61K 31/505

US Classification:

514267, 544249, 544250

Abstract:

Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

US Patent:

8436005, May 7, 2013

Filed:

Mar 27, 2009

Appl. No.:

12/413168

Inventors:

Huaqing Liu - Buffalo Grove IL, US
Irene Drizin - Wadsworth IL, US
John R. Koenig - Chicago IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Chen Zhao - Libertyville IL, US
Brian D. Wakefield - Vernon Hills IL, US
Lawrence A. Black - Libertyville IL, US
Robert J. Altenbach - Chicago IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 403/04
C07D 401/04
A61K 31/517

US Classification:

5142662, 51426623, 544253

Abstract:

Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

US Patent:

8580968, Nov 12, 2013

Filed:

Mar 1, 2012

Appl. No.:

13/410206

Inventors:

Lawrence A. Black - Libertyville IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Gregory A. Gfesser - Lindenhurst IL, US
Brian D. Wakefield - Vernon Hills IL, US
Robert J. Altenbach - Chicago IL, US
Huaqing Liu - Buffalo Grove IL, US
Chen Zhao - Libertyville IL, US
Gin C. Hsieh - Long Grove IL, US

Assignee:

AbbVie Inc. - North Chicago IL

International Classification:

A61K 31/454
A61K 31/4545
A61K 31/428
C07D 417/04
C07D 417/14

US Classification:

548162, 544135, 544333, 544238, 546193, 546198, 5142338, 514367, 514321, 514374, 514318, 51425206

Abstract:

Compounds of formula (I).

US Patent:

8648069, Feb 11, 2014

Filed:

Dec 4, 2008

Appl. No.:

12/327991

Inventors:

Brian D. Wakefield - Vernon Hills IL, US
Helmut Mack - Ludwigshafen, DE
Sean C. Turner - Mannheim, DE
Alan F. Gasiecki - Vernon Hills IL, US
Vijaya J. Gracias - West Newton IN, US
Kathy A. Sarris - Deerfield IL, US
Douglas M. Kalvin - Buffalo Grove IL, US
Melissa J. Michmerhuizen - Beach Park IL, US
Qi Shuai - Dekalb IL, US
Jyoti R. Patel - Libertyville IL, US
Margaretha Bakker - Seeheim-Jugenheim, DE
Nicole Teusch - Wuelfrath, DE
Eric F. Johnson - Temecula CA, US
Peter J. Kovar - Chicago IL, US
Stevan W. Djuric - Libertyville IL, US
Andrew J. Long - Chelmsford MA, US
Anil Vasudevan - Union Grove WI, US
Dawn George - Charlton MA, US
Lu Wang - Worcester MA, US
Biqin Li - Northborough MA, US
N. St. John Moore - Shrewsbury MA, US
Adrian D. Hobson - Shrewsbury MA, US
Keith W. Woods - Libertyville IL, US
Julie M. Miyashiro - Morton Grove IL, US
Thomas D. Penning - Elmhurst IL, US

Assignee:

AbbVie Inc. - North Chicago IL

International Classification:

A61K 31/541
A61K 31/5377
A61K 31/496
A61K 31/454
A61K 31/4192
C07D 417/14
C07D 405/14
C07D 401/14
C07D 403/04
C07D 403/14

US Classification:

5142282, 5142348, 51425406, 514322, 514403, 514405, 544 582, 544140, 544371, 546199

Abstract:

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts,.