Brian Asher Wall

US Patent:

20200392346, Dec 17, 2020

Filed:

Aug 26, 2020

Appl. No.:

17/003591

Inventors:

- Franklin Lakes NJ, US
Yongchao Liang - Irvine CA, US
Brian Wall - Poway CA, US
David Moureau - San Marcos CA, US

International Classification:

C09B 69/10
G01N 33/58

Abstract:

Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.

US Patent:

20200002540, Jan 2, 2020

Filed:

Mar 28, 2019

Appl. No.:

16/368513

Inventors:

- Franklin Lakes NJ, US
Yongchao Liang - Irvine CA, US
Brian Wall - Poway CA, US
David Moureau - San Marcos CA, US

International Classification:

C09B 69/10
G01N 33/58

Abstract:

Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.