Bronislaw T Czech

US Patent:

20060172425, Aug 3, 2006

Filed:

Feb 1, 2005

Appl. No.:

11/048601

Inventors:

Ralf Neigl - Yorktown Heights NY, US
Michael Sommer - Monroe NY, US
Bronislaw Czech - Cortlandt Manor NY, US
Horst Berneth - Leverkusen, DE
Alan Toth - Newburgh NY, US
Josef-Walter Stawitz - Odenthal, DE

Assignee:

BAYER HEALTHCARE, LLC - Tarrytown NY

International Classification:

G01N 33/00

US Classification:

436018000

Abstract:

A colored intercapsular buffer solution is used to reduce erroneous results from the absorption or carryover of small amounts of reagent R1 and/or R2 into the intercapsular buffer solution segment in the analytical line of a capsule chemistry liquid analysis system in an automated clinical analyzer. The absorption of small amounts of the regent R1 and/or R2 in the intercapsular buffer solution leads to erroneous results in the analysis of the test sample, S, because the R1 and/or R2 that is carried over and absorbed into the buffer does not react with test sample S. The R1/R2 carryover can be measured and determined by monitoring the absorbance of the colored buffer solution, wherein the change in absorbance can be measured and compared to a reference value. The sample is automatically retested if an unacceptable change in absorbance occurs. The colored buffer solution comprises a phthalocyanine dye, an aqueous solution of a base at a pH of about 9-12, a surfactant to reduce surface tension and improve flow characteristics of the intercapsular colored buffer reagent through the analytical line, and a chelating agent to reduce the adverse effects of metal contaminants.

US Patent:

48452122, Jul 4, 1989

Filed:

Aug 17, 1988

Appl. No.:

7/232976

Inventors:

Bronislaw P. Czech - Peekskill NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY

International Classification:

C07D27308

US Classification:

540469

Abstract:

The invention relates to a process in which a variety of cryptahemispherands bearing a chromogenic group attached to the partially preorganized moiety may be synthesized. The procedure of the present invention allows preparation of preferred chromogenic cryptahemispherands of the general formula: ##STR1## wherein: R, is same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl; R', same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl; R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl; Z is halogen; Y is an electron withdrawing group, e. g. , CN, NO. sub. 2, CF. sub. 3, COOR; m is 1 to 3; n is 1 to 3; a is 1 to 3; b is 1 to 3; k is 1 to 3; l is 1 to 3; and x is 2 to 4.

US Patent:

51871033, Feb 16, 1993

Filed:

Jan 31, 1991

Appl. No.:

7/648073

Inventors:

Bronislaw P. Czech - Peekskill NY
Eddy Chapoteau - Brooklyn NY
Anand Kumar - Monroe NY

Assignee:

Miles Inc. - Tarrytown NY

International Classification:

G01N 3320
G01N 2178

US Classification:

436 79

Abstract:

A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2, R. sub. 1 and R. sub. 2, same or different, are hydrogen, lower alkyl, lower alkenyl, or lower alkylidene; and Q is a chromogenic moiety capable of providing a detectable response upon complexation of said compound with lithium ion and has the structure: ##STR2## wherein: X is CH, C--OH or N; and Z is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo. A reagent composition and synthesis of a preferred chromogenic cryptand are also disclosed.

US Patent:

50119249, Apr 30, 1991

Filed:

May 9, 1989

Appl. No.:

7/349465

Inventors:

Donald J. Cram - Los Angeles CA
Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Roger C. Helgeson - Canuga Park CA
Anand Kumar - Southfields NY
Koon-Wah Leong - Ossining NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY
The Regents of The University of California - Berkeley CA

International Classification:

C07D49808
C07D27300

US Classification:

540469

Abstract:

The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation; a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4. A test device utilizing one or more of the compounds for performing such measurements is also disclosed.

US Patent:

51457873, Sep 8, 1992

Filed:

Dec 5, 1991

Appl. No.:

7/803134

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Miles, Inc. - Tarrytown NY

International Classification:

G01N 2178
G01N 3320

US Classification:

436 79

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic crypt and compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and --Q-- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 to 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

US Patent:

52623300, Nov 16, 1993

Filed:

Feb 27, 1992

Appl. No.:

7/842860

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Wolodymyr I. Zazulak - East Elmhurst NY

Assignee:

Miles Inc. - Tarrytown NY

International Classification:

G01N 3384
G01N 3320
C09B 2900

US Classification:

436 79

Abstract:

A chromogenic compound found to be especially selective in the determination of calcium in blood of the general formula (I): ##STR1## where: R is hydrogen or lower alkyl; X is CH. sub. 2, CH. sub. 2 CH. sub. 2, CH. dbd. CH, O, S, SO. sub. 2, S--S, or NR; X is CH, C--OH or N; M is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinoneimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo, or isothiazolyl-5-azo; k is 1; l is 0 or 1; and n is 0 or 1.

US Patent:

50454757, Sep 3, 1991

Filed:

Jun 1, 1988

Appl. No.:

7/201576

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY

International Classification:

G01N 2178

US Classification:

436 74

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and --Q-- is ##STR2## wherein X and CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

US Patent:

49923811, Feb 12, 1991

Filed:

Apr 15, 1987

Appl. No.:

7/038679

Inventors:

Donald J. Cram - Los Angeles CA
Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Roger C. Helgeson - Canuga Park CA
Anand Kumar - Southfields NY
Koon-Wah Leong - Ossining NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY
The Regents of the University of California - Berkeley CA

International Classification:

G01N 2178

US Classification:

436 74

Abstract:

The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, methods of using the chromogenic hemispherands and test devices containing the chromogenic hemispherands. The chromogenic hemispherands of the invention have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation; m is 1 to about 3; n is 0 to about 3; P is an aliphatic or aromatic subunit, e. g. , --CR. sub. 2 CR. sub. 2 OCR. sub. 2 CR. sub. 2 --, ##STR2##.