Bruce Allen Bonenberger

US Patent:

54550475, Oct 3, 1995

Filed:

Jun 15, 1994

Appl. No.:

8/259839

Inventors:

Robert J. Bequette - Evansville IN
Bruce A. Bonenberger - Evansville IN
Claude E. Gallian - Newburgh IN
John R. Reckelhoff - Evansville IN

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

A61K 932
A61K 942

US Classification:

424476

Abstract:

A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.

US Patent:

49561820, Sep 11, 1990

Filed:

Mar 16, 1989

Appl. No.:

7/324167

Inventors:

Robert J. Bequette - Evansville IN
Bruce A. Bonenberger - Evansville IN
Claude E. Gallian - Newburgh IN
John R. Reckelhoff - Evansville IN

Assignee:

Bristol-Myers Company - New York NY

International Classification:

A61K 942

US Classification:

424476

Abstract:

A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.

US Patent:

53728238, Dec 13, 1994

Filed:

Oct 22, 1992

Appl. No.:

7/965096

Inventors:

Robert J. Bequette - Evansville IN
Bruce A. Bonenberger - Evansville IN
Claude E. Gallian - Newburgh IN
John R. Reckelhoff - Evansville IN

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

A61K 920
A61K 916

US Classification:

424464

Abstract:

A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.