- Lexington MA, US Angela NORTON - Reading MA, US Kevin HOLMES - Belmont MA, US David Bruce LLOYD - Leland NC, US Bryan James GOODWIN - Lexington MA, US Rongxin SHI - Waltham MA, US Sujit JAIN - Lexington MA, US Chuan SHEN - West Roxbury MA, US
Assignee:
Shire-NPS Pharmaceuticals, Inc. - Lexington MA
International Classification:
C07K 14/635 A61K 9/00 C07K 1/16 A61P 5/18
Abstract:
The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.
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