Bryan L Roth

US Patent:

20100256142, Oct 7, 2010

Filed:

Sep 25, 2009

Appl. No.:

12/567573

Inventors:

Jeffrey Aube - Lawrence KS, US
Bryan L. Roth - Durham NC, US
Partha Ghosh - Lawrence KS, US
Kevin J. Frankowski - Lawrence KS, US

International Classification:

A61K 31/5377
C07D 217/24
A61K 31/472
C07D 401/02
A61K 31/497
C07D 413/08
C07D 311/76
A61K 31/352
C07D 405/08
A61K 31/453
A61P 25/30
A61P 25/16
A61P 25/24
A61P 9/00
A61P 13/12
A61P 29/00
A61P 25/20
A61P 25/06

US Classification:

5142352, 546141, 514309, 544405, 51425505, 544116, 549283, 514456, 544376, 51425411, 546196, 514320

Abstract:

A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.