Bryan C Tieman from Glendale Heights, IL

Us Patents

Human Ring Specific Bnp Antibodies
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US Patent:

20060183154, Aug 17, 2006
Filed:

May 23, 2005
Appl. No.:

11/135040
Inventors:

Jessie Shih - Lake Forest IL, US
Joan Tyner - Beach Park IL, US
Matthew Matias - Green Oaks IL, US
Mary Pinkus - Chicago IL, US
Susan Brophy - Lindenhurst IL, US
David Dagfal - Kenosha WI, US
David Hawksworth - Round Lake Beach IL, US
Bryan Tieman - Elmhurst IL, US
International Classification:

G01N 33/53
C12N 5/06
C07K 16/18
US Classification:

435007100, 435326000, 530388250
Abstract:

The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.

Immunoassays And Kits For The Detection Of Ngal
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US Patent:

20090123946, May 14, 2009
Filed:

Dec 5, 2008
Appl. No.:

12/329331
Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
Frank C. Grenier - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Ryan F. Workman - Gurnee IL, US
Robert N. Ziemann - Lindenhurst IL, US
Lowell J. Tyner - Chicago IL, US
Assignee:

ABBOTT LABORATORIES - Abbott Park IL
International Classification:

G01N 33/53
US Classification:

435 721
Abstract:

The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

Antibodies That Bind To Mammalian Ngal And Uses Thereof
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US Patent:

20090124022, May 14, 2009
Filed:

Apr 16, 2008
Appl. No.:

12/104413
Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Robert N. Ziemann - Lindenhurst IL, US
Lowell J. Tyner - Chicago IL, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

G01N 33/566
C07K 16/18
C12N 5/06
US Classification:

436501, 5303879, 5303873, 5303872, 435346
Abstract:

The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

Antibodies And Improved Test Sample Handling Methods For Use In Assays For Myeloperoxidase
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US Patent:

20090148866, Jun 11, 2009
Filed:

May 16, 2008
Appl. No.:

12/122244
Inventors:

Saul A. Datwyler - Evanston IL, US
David J. Hawksworth - Lake Villa IL, US
Stephen C. Hsu - Buffalo Grove IL, US
Matthew S. Matias - Green Oaks IL, US
David P. Pacenti - Gurnee IL, US
Mary S. Pinkus - Chicago IL, US
Jessie W. Shih - Lake Forest IL, US
Bryan C. Tieman - Elmhurst IL, US
Joan D. Tyner - Beach Park IL, US
Robert N. Ziemann - Lindenhurst IL, US
Lowell J. Tyner - Chicago IL, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

G01N 33/573
C12N 5/06
C12Q 1/28
C07K 16/18
US Classification:

435 74, 435338, 53038826, 435 28
Abstract:

The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.

Antibodies That Bind To Mammalian Ngal And Uses Thereof
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US Patent:

20090263894, Oct 22, 2009
Filed:

Dec 5, 2008
Appl. No.:

12/329357
Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Robert N. Ziemann - Lindenhurst IL, US
Assignee:

ABBOTT LABORATORIES - Abbott Park IL
International Classification:

C12N 5/06
C07K 16/18
US Classification:

435328, 5303879, 5303872, 5303873
Abstract:

The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

Immunoassays And Kits For The Detection Of Ngal
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US Patent:

20090269777, Oct 29, 2009
Filed:

Apr 16, 2008
Appl. No.:

12/104410
Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
Frank C. Grenier - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Lowell J. Tyner - Chicago IL, US
Ryan F. Workman - Waukegan IL, US
Robert N. Ziemann - Lindenhurst IL, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

G01N 33/53
US Classification:

435 71
Abstract:

The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

Immunoassays And Kits For The Detection Of Ngal
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US Patent:

20100227775, Sep 9, 2010
Filed:

May 21, 2010
Appl. No.:

12/784548
Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
Frank C. Grenier - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Ryan F. Workman - Gurnee IL, US
Robert N. Ziemann - Lindenhurst IL, US
Assignee:

ABBOTT LABORATORIES - Abbott Park IL
International Classification:

C40B 30/04
G01N 33/53
US Classification:

506 9, 435 792
Abstract:

The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

Soluble Fms-Like Tyrosine Kinase-1 (Sflt-1) Antibody And Related Composition, Kit, Methods Of Using, And Materials And Method For Making
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US Patent:

20130040407, Feb 14, 2013
Filed:

Oct 15, 2012
Appl. No.:

13/652402
Inventors:

Abbott Laboratories - , US
Saul A. Datwyler - Evanston IL, US
David J. Hawksworth - Lake Villa IL, US
Don C. Laird - Mundelein IL, US
Sharmila Manoj - Arlington Heights IL, US
Dominick L. Pucci - Libertyville IL, US
Bryan C. Tieman - Elmhurst IL, US
Joan D. Tyner - Beach Park IL, US
Zhiguang Yu - Libertyville IL, US
International Classification:

G01N 33/577
G01N 33/566
US Classification:

436501
Abstract:

An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.