Bryan C Tieman

US Patent:

7939069, May 10, 2011

Filed:

May 8, 2007

Appl. No.:

11/745963

Inventors:

Susan E. Brophy - Lindenhurst IL, US
Joan D. Tyner - Beach Park IL, US
Bryan C. Tieman - Elmhurst IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 39/395
C12N 5/10
G01N 33/53

US Classification:

4241331, 4241351, 4241391, 4241411, 4241421, 4241451, 435328, 435331, 435336, 435358, 435975

Abstract:

The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.

US Patent:

7998480, Aug 16, 2011

Filed:

Aug 11, 2008

Appl. No.:

12/189232

Inventors:

Susan E. Brophy - Lindenhurst IL, US
Joan D. Tyner - Beach Park IL, US
Bailin X. Tu - Lake Bluff IL, US
Mary S. Pinkus - Chicago IL, US
Jessie W. Shih - Lake Forest IL, US
Bryan C. Tieman - Elmhurst IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 39/395
C12N 5/10
G01N 33/53

US Classification:

4241331, 4241351, 4241391, 4241411, 4241421, 4241451, 435328, 435331, 435336, 435358, 435975

Abstract:

The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.

US Patent:

8349325, Jan 8, 2013

Filed:

Dec 21, 2009

Appl. No.:

12/643847

Inventors:

Susan E. Brophy - Lindenhurst IL, US
Saul A. Datwyler - Evanston IL, US
David J. Hawksworth - Lake Villa IL, US
Don C. Laird - Mundelein IL, US
Sharmila Manoj - Arlington Heights IL, US
Dominick L. Pucci - Libertyville IL, US
Bryan C. Tieman - Elmhurst IL, US
Joan Tyner - Beach Park IL, US
Zhiguang Yu - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 39/395
C07K 16/18
C07K 16/28

US Classification:

4241331, 4241301, 4241411, 4241431, 5303871, 5303881, 5303882

Abstract:

An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.

US Patent:

20060183154, Aug 17, 2006

Filed:

May 23, 2005

Appl. No.:

11/135040

Inventors:

Jessie Shih - Lake Forest IL, US
Joan Tyner - Beach Park IL, US
Matthew Matias - Green Oaks IL, US
Mary Pinkus - Chicago IL, US
Susan Brophy - Lindenhurst IL, US
David Dagfal - Kenosha WI, US
David Hawksworth - Round Lake Beach IL, US
Bryan Tieman - Elmhurst IL, US

International Classification:

G01N 33/53
C12N 5/06
C07K 16/18

US Classification:

435007100, 435326000, 530388250

Abstract:

The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.

US Patent:

20090123946, May 14, 2009

Filed:

Dec 5, 2008

Appl. No.:

12/329331

Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
Frank C. Grenier - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Ryan F. Workman - Gurnee IL, US
Robert N. Ziemann - Lindenhurst IL, US
Lowell J. Tyner - Chicago IL, US

Assignee:

ABBOTT LABORATORIES - Abbott Park IL

International Classification:

G01N 33/53

US Classification:

435 721

Abstract:

The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

US Patent:

20090124022, May 14, 2009

Filed:

Apr 16, 2008

Appl. No.:

12/104413

Inventors:

Larry G. Birkenmeyer - Glenview IL, US
Suresh M. Desai - Libertyville IL, US
David J. Hawksworth - Lake Villa IL, US
Edward T. Olejniczak - Grayslake IL, US
Qiaoqiao Ruan - Round Lake IL, US
Robert W. Siegel - Fountaintown IN, US
Sergey Y. Tetin - Lindenhurst IL, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Robert N. Ziemann - Lindenhurst IL, US
Lowell J. Tyner - Chicago IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33/566
C07K 16/18
C12N 5/06

US Classification:

436501, 5303879, 5303873, 5303872, 435346

Abstract:

The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

US Patent:

20090148866, Jun 11, 2009

Filed:

May 16, 2008

Appl. No.:

12/122244

Inventors:

Saul A. Datwyler - Evanston IL, US
David J. Hawksworth - Lake Villa IL, US
Stephen C. Hsu - Buffalo Grove IL, US
Matthew S. Matias - Green Oaks IL, US
David P. Pacenti - Gurnee IL, US
Mary S. Pinkus - Chicago IL, US
Jessie W. Shih - Lake Forest IL, US
Bryan C. Tieman - Elmhurst IL, US
Joan D. Tyner - Beach Park IL, US
Robert N. Ziemann - Lindenhurst IL, US
Lowell J. Tyner - Chicago IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33/573
C12N 5/06
C12Q 1/28
C07K 16/18

US Classification:

435 74, 435338, 53038826, 435 28

Abstract:

The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.

US Patent:

20090203037, Aug 13, 2009

Filed:

Dec 23, 2008

Appl. No.:

12/342641

Inventors:

Susan E. Brophy - Lindenhurst IL, US
David J. Hawksworth - Lake Villa IL, US
Dinesh O. Shah - Libertyville IL, US
Robert W. Siegel - Fountaintown IN, US
Bryan C. Tieman - Elmhurst IL, US
Bailin Tu - Libertyville IL, US
Joan D. Tyner - Beach Park IL, US
Lowell J. Tyner - Chicago IL, US
Robert N. Ziemann - Lindenhurst IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33/53
C07K 16/20
C12N 1/00
C07H 21/04
C07K 1/14

US Classification:

435 71, 5303891, 5303873, 435243, 536 2353, 530413

Abstract:

The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of