Bryce V Plapp from 902 Talwrn Ct, Iowa City, IA 52246, age 85, Phone: (319)6211285

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Location:

Iowa City, IA

Industry:

Biotechnology

Work:

U Iowa
Professor

Autoinducer Synthase Modulating Compounds And Uses Thereof
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US Patent:

6723321, Apr 20, 2004
Filed:

Jan 6, 1999
Appl. No.:

09/227488
Inventors:

E. Peter Greenberg - Iowa City IA
Bryce V. Plapp - Iowa City IA
Matthew R. Parsek - Iowa City IA
Assignee:

The Board of Trustees of the University of Illinois - Urbana IL
The University of Iowa Research Foundation - Iowa City IA
International Classification:

A61K 3900
US Classification:

4241851, 424190, 424832, 435 9132, 435 914, 435 9141, 435 9152, 435 934, 4352523, 530300, 530305, 536 231, 935 9, 935 10, 935 13, 935 14, 935 16, 935 19, 935 22, 935 23, 935 24, 935 27, 935 88
Abstract:

Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

Autoinducer Synthase Modulating Compounds And Uses Therefore
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US Patent:

20040152660, Aug 5, 2004
Filed:

Mar 5, 2004
Appl. No.:

10/794922
Inventors:

John Cronan - Urbana IL, US
Bryce Plapp - Iowa City IA, US
E. Greenberg - Iowa City IA, US
Matthew Parsek - Iowa City IA, US
Assignee:

The Board of Trustees of the University of Illinois - Urbana IL
International Classification:

A61K031/7076
US Classification:

514/046000, 514/047000
Abstract:

Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

Inhibition Of Alcohol Metabolism By Tetramethylene Sulfoxides
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US Patent:

44825684, Nov 13, 1984
Filed:

Oct 17, 1983
Appl. No.:

6/542482
Inventors:

Bryce V. Plapp - Iowa City IA
Vijay K. Chadha - Coralville IA
Assignee:

University of Iowa Research Foundation - Iowa City IA
International Classification:

A61K 3138
C07D33300
US Classification:

424275
Abstract:

Tetramethylene sulfoxide and its substituted derivatives have been found to be exceptionally potent inhibitors of oxidation of alcohols by liver alcohol dehydrogenases.

Bryce V Plapp