Caibin Xiao

US Patent:

7283245, Oct 16, 2007

Filed:

Jan 20, 2004

Appl. No.:

10/760438

Inventors:

Caibin Xiao - Harleysville PA, US
Scott M. Boyette - New Hope PA, US
Radislav A. Potyrailo - Niskayuna NY, US

Assignee:

General Electric Company - Fairfield CT

International Classification:

G01N 21/27
G01N 21/47
G01N 21/00
G06F 19/00

US Classification:

356446, 356445, 356434, 702 28, 422 8205

Abstract:

A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

US Patent:

7723120, May 25, 2010

Filed:

Oct 26, 2005

Appl. No.:

11/259643

Inventors:

Caibin Xiao - Harleysville PA, US
Radislav A. Potyrailo - Niskayuna NY, US
William G. Morris - Rexford NY, US
Scott M. Boyette - New Hope PA, US
LiJie Yu - Clifton Park NY, US
Theodore J. Cecconie - Buckingham PA, US
Andrew M. Leach - Clifton Park NY, US
Prashant V. Shrikhande - Trevose PA, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 21/00
G06K 9/38
C12Q 1/68
G01N 33/543
F16L 7/00

US Classification:

436164, 436518, 422 8205, 382273, 435 6, 137375

Abstract:

Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

US Patent:

7807473, Oct 5, 2010

Filed:

Oct 26, 2005

Appl. No.:

11/259506

Inventors:

Radislav A. Potyrailo - Niskayuna NY, US
Timothy M. Sivavec - Clifton Park NY, US
Caibin Xiao - Harleysville PA, US
Theodore J. Cecconie - Buckingham PA, US
Lamyaa Hassib - Niskayuna NY, US
Andrew M. Leach - Clifton Park NY, US
David B. Engel - The Woodlands TX, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 21/00

US Classification:

436164, 436166, 436167, 436169, 436171, 436172, 436800, 436805, 422 50

Abstract:

A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.

US Patent:

7883898, Feb 8, 2011

Filed:

May 7, 2007

Appl. No.:

11/800746

Inventors:

Bingzhi Chen - Pudong, CN
Weiyi Cui - Piscataway NJ, US
Li Zhang - Pudong, CN
Caibin Xiao - Harleysville PA, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 31/16
G01N 21/00

US Classification:

436163, 436 2, 436 8, 422 55, 422 8205, 73 102

Abstract:

Systems and methods are described for measuring pH of low alkalinity samples. The present invention provides a sensor array comprising a plurality of pH indicators, each indicator having a different indicator concentration. A calibration function is generated by applying the sensor array to a sample solution having a known pH such that pH responses from each indicator are simultaneously recorded versus indicator concentration for each indicator. Once calibrated, the sensor array is applied to low alkalinity samples having unknown pH. Results from each pH indicator are then compared to the calibration function, and fitting functions are extrapolated to obtain the actual pH of the low alkalinity sample.

US Patent:

7977660, Jul 12, 2011

Filed:

Mar 10, 2008

Appl. No.:

12/045217

Inventors:

Radislav Alexandrovich Potyrailo - Niskayuna NY, US
Scott Martell Boyette - New Hope PA, US
Glenn Alfred Johnson - Devon PA, US
William Guy Morris - Rexford NY, US
Ronald James Wroczynski - Schenectady NY, US
Andrew Michael Leach - Clifton Park NY, US
Peter Miller - New London CT, US
Caibin Xiao - Harleysville PA, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

G01N 33/00
G01N 15/00

US Classification:

250573, 250575, 250576, 73 5301

Abstract:

An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.

US Patent:

8076153, Dec 13, 2011

Filed:

Dec 29, 2010

Appl. No.:

12/980791

Inventors:

Bingzhi Chen - Shanghai, CN
Weiyi Cui - Piscataway NJ, US
Li Zhang - Shanghai, CN
Caibin Xiao - Harleysville PA, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 31/16
G01N 21/00

US Classification:

436163, 436164, 422 8205, 422 8209

Abstract:

Systems and methods are described for measuring pH of low alkalinity samples. The present invention provides a sensor array comprising a plurality of pH indicators, each indicator having a different indicator concentration. A calibration function is generated by applying the sensor array to a sample solution having a known pH such that pH responses from each indicator are simultaneously recorded versus indicator concentration for each indicator. Once calibrated, the sensor array is applied to low alkalinity samples having unknown pH. Results from each pH indicator are then compared to the calibration function, and fitting functions are extrapolated to obtain the actual pH of the low alkalinity sample.

US Patent:

8105552, Jan 31, 2012

Filed:

Mar 24, 2010

Appl. No.:

12/730550

Inventors:

Caibin Xiao - Harleysville PA, US
Radislav A. Potyrailo - Niskayuna NY, US
William G. Morris - Rexford NY, US
Scott M. Boyette - New Hope PA, US
LiJie Yu - Clifton Park NY, US
Theodore J. Cecconie - Buckingham PA, US
Andrew M. Leach - Clifton Park PA, US
Prashant V. Shrikhande - Trevose PA, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

B01L 3/00
G01P 3/00
G01N 31/00

US Classification:

422502, 702 22, 702147

Abstract:

Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

US Patent:

8133741, Mar 13, 2012

Filed:

Aug 22, 2006

Appl. No.:

11/507689

Inventors:

Radislav A. Potyrailo - Niskayuna NY, US
Prashant V. Shrikhande - Trevose PA, US
Scott M. Boyette - New Hope PA, US
Caibin Xiao - Harleysville PA, US
Andrew M. Leach - Clifton Park NY, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 21/00

US Classification:

436164, 436518, 436 95, 422 58, 422 681, 422 8205, 435 6, 4352872, 222134, 382273

Abstract:

Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.