Cameron Seath Gibb

US Patent:

20130079526, Mar 28, 2013

Filed:

Mar 3, 2011

Appl. No.:

13/582224

Inventors:

Scott Jeffrey Greenfield - Delmar NY, US
Cameron Seath Gibb - Durham NC, US
Rajendra Kumar Reddy Gadikota - Kompalli, IN

Assignee:

Knopp Neurosciences Inc. - Pittsburgh PA

International Classification:

C07D 277/82

US Classification:

548164

Abstract:

Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro--(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.

US Patent:

20100087636, Apr 8, 2010

Filed:

Mar 13, 2008

Appl. No.:

12/450094

Inventors:

Paul Bruzinski - Clifton Park NY, US
Xuejun Liu - Arcadia CA, US
Cameron Gibb - Delmar NY, US
Pedro E. Hernandez-Abad - Arroyo PR, US

International Classification:

C07H 19/16
C07H 1/00

US Classification:

536 276, 536 553

Abstract:

The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.

US Patent:

20220304304, Sep 29, 2022

Filed:

Jun 4, 2020

Appl. No.:

17/615637

Inventors:

- Mumbai, IN
Emma Louise Hawkins - Evesham, GB
Cameron Seath Gibb - Cary NC, US
Alexander Kenneth Zorzitto - Guelph, CA
Sarah Jane Maude - Evesham, GB
Sheldon Park - Guelph, CA

International Classification:

A01N 33/26
A01N 59/20

Abstract:

The present invention relates to agricultural compositions containing dicarboxylic acid hydrazides and transition metal ions, and the preparation thereof. The compositions are useful in the treatments of plants or seeds as an anti-sprout agent, growth regulator and/or pest control agent. In particular, it relates to maleic hydrazide combined with copper, nickel, manganese, iron or zinc. The transition metal ions improve the storage stability of the dicarboxylic acid hydrazide and prevent generation of free hydrazine.

US Patent:

20210321613, Oct 21, 2021

Filed:

Jun 12, 2019

Appl. No.:

17/251005

Inventors:

- Cary NC, US
Vic Prasad - Leawood KS, US
Cameron Gibb - Apex NC, US
Christopher Lynn Larson - Cary NC, US

International Classification:

A01N 43/32
C07D 341/00

Abstract:

A process for preparation of thiocyclam base and salt. A method of manufacturing N,N-dimethyl-1,2,3-trithian-5-ylainine hydrochloride is described including the steps of: providing a mixture of thiosulfuric acid S, S′[2-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; adding an aqueous saline solution to the mixture of thiosulfuric acid S, S′-[-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; separating the phases of the mixture; collecting the solids from the mixture using filtration; washing the solids with organic solvent; and drying the solids, where the dried solids are methyl-1,2,3-trithian-5-ylamine hydrochloride, and where the yield of the N,N-dimethyl-1,2,3-trithian-5-ylamine hydrochloride is increased by incorporation of a body charge of diatomaceous earth into the saline addition step, forming a mixture of the diatomaceous C earth with the composition of this step, and filtering the charged mixture through a diatomaceous earth media prior to the separation step.

US Patent:

20200352167, Nov 12, 2020

Filed:

Jan 23, 2019

Appl. No.:

16/961377

Inventors:

- Cary NC, US
Christopher L. Larson - Cary NC, US
Cameron Seath Gibb - Apex NC, US

International Classification:

A01N 43/653
A01N 25/04
A01N 41/06
A01N 47/38

Abstract:

A flucarbazone sodium hemihydrate method and composition. A method of suppressing growth of grass and broadleaf weeds is described including applying to said weeds at least one dust-free composition comprising flucarbazone sodium-hemihydrate as an active ingredient. A method for preparing flucarbazone sodium-hemihydrate is also described including treating 4,5-dihydro-3-methoxy-4-methyl-5-oxo-N-[[2-(trifluoromethoxy)phenyl]sulfonyl]-1H-1,2,4-triazole-1-carboxamide (MSU) with aqueous sodium hydroxide under pH-controlled conditions; and confirming that a hemihydrate flucarbazone sodium has been obtained.

US Patent:

20200255459, Aug 13, 2020

Filed:

Apr 28, 2020

Appl. No.:

16/860182

Inventors:

- Cary NC, US
David HUANG - KUNSHAN, CN
Kamal KATARIA - Maharashtra, IN
Christopher Lynn LARSON - Cary NC, US
Cameron Seath GIBB - Apex NC, US
Stephen CORNES - American Canyon CA, US

International Classification:

C07F 9/24

Abstract:

Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PClto form PSCl, reacting the PSClformed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CHCl, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CHCl. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CHClat all times.

US Patent:

20200157043, May 21, 2020

Filed:

Nov 15, 2019

Appl. No.:

16/685703

Inventors:

- Cary NC, US
Vic PRASAD - Leawood KS, US
Christopher Lynn LARSON - Cary NC, US
Cameron Seath GIBB - Apex NC, US
Kirit DESAI - Gujarat, IN
Ashwani GUPTA - Gujarat, IN
Girish SISODE - Gujarat, IN

Assignee:

Arysta LifeScience Inc. - Cary NC

International Classification:

C07C 253/30

Abstract:

Disclosed herein a process preparation of 2,6-dichlorobenzonitrile. A process of making high yield, high purity 2,6-dichlorobenzonitrile including the selective de-nitrochlorination of 2-chloro-6-nitrohenzonitrile by treatment of the 2-chloro-6-nitrobenzonitrile with chlorine gas.

US Patent:

20200024293, Jan 23, 2020

Filed:

Jul 19, 2018

Appl. No.:

16/040136

Inventors:

- Cary NC, US
David HUANG - Kunshan, CN
Kamal KATARIA - Maharashtra, IN
Christopher Lynn LARSON - Cary NC, US
Cameron Seath GIBB - Apex NC, US
Stephen CORNES - American Canyon CA, US

Assignee:

Arysta LifeScience Inc. - Cary NC

International Classification:

C07F 9/24

Abstract:

Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PClto form PSCl, reacting the PSClformed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CHCl, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CHCl. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos, and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CHClat all times.