Carissa M Thomas

US Patent:

20130149291, Jun 13, 2013

Filed:

Feb 13, 2013

Appl. No.:

13/765947

Inventors:

James Versalovic - Houston TX, US
Carissa Michelle Thomas - Houston TX, US
Eamonn Connolly - Lindingo, SE

International Classification:

A61K 35/74
A61K 31/4172

US Classification:

424 9345, 435 611, 4352529

Abstract:

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an. active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production, of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.

US Patent:

20130022586, Jan 24, 2013

Filed:

Jul 19, 2012

Appl. No.:

13/552686

Inventors:

James Versalovic - Houston TX, US
Carissa Michelle Thomas - Houston TX, US
Eamonn Connolly - Lindingo, SE

International Classification:

A61K 35/74
A61P 1/00
C12N 1/20
A61P 15/02
G01N 33/53
C12Q 1/04
A61P 29/00
A61P 1/04

US Classification:

424 9345, 435 792, 435 34, 4352529

Abstract:

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.

US Patent:

20180264055, Sep 20, 2018

Filed:

May 23, 2018

Appl. No.:

15/987210

Inventors:

- Stockholm, SE
Carissa Michelle Thomas - Houston TX, US
Eamonn Connolly - Lindingo, SE

International Classification:

A61K 35/747
A61K 35/74
A23L 33/135
A61K 31/4172
A61K 31/7004
G01N 33/569
C12Q 1/04
A61K 45/06
A61K 35/741
A23L 33/175
A61K 35/00

Abstract:

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.

US Patent:

20170020936, Jan 26, 2017

Filed:

Oct 10, 2016

Appl. No.:

15/289666

Inventors:

- Stockholm, SE
Carissa Michelle Thomas - Houston TX, US
Eamonn Connolly - Lindingo, SE

International Classification:

A61K 35/747
A61K 31/7004
A23L 33/175
A61K 45/06

Abstract:

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.