Medical University of South Carolina Jun 2008 - Jul 2012
Assistant Professor
Medical University of South Carolina Jun 2008 - Jul 2012
Associate Professor of Immunology
Papworth Hospital Nhs Foundation Trust Jan 1997 - Jun 2004
Chief Biomedical Scientist
Milton Keynes Hospital Nhs Foundation Trust Oct 1993 - Dec 1996
Biomedical Scientist
Education:
University of West of England 2000 - 2004
Doctorates, Doctor of Philosophy, Immunology
Kingston University 1990 - 1993
Bachelors, Bachelor of Science
Hele's School 1983 - 1990
Medical University of South Carolina
Skills:
Immunology Immunohistochemistry Biochemistry Flow Cytometry Western Blotting Clinical Research Immunofluorescence Microscopy Rt Pcr Pcr Fluorescence Microscopy Biomedical Sciences Pathology Histology Laboratory Medicine
Stephen Tomlinson - Mount Pleasant SC, US Songqing He - Charleston SC, US Carl Atkinson - Mount Pleasant SC, US
International Classification:
A61K 39/395 A61P 1/16 A61K 38/17
US Classification:
4241341, 514 209
Abstract:
Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.
Organ Preconditioning Formulation With Mitochondrial Elongating Agents
Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
Compositions And Methods For Treating And Preventing Transplant-Associated Injury
Described herein are compositions and methods for treating or preventing an injury associated with transplant. Specifically, the disclosure provides a composition for treating or preventing an injury associated with transplantation, comprising (a) a targeted inhibitor molecule wherein the targeted inhibitor molecule comprises a targeting portion and an inhibitor portion, wherein the molecule inhibits complement pathways, and (b) a sub-therapeutic dose of an immunosuppressant agent. Further provided are methods of treating or preventing an injury associated with transplantation with activated complement by using the compositions.
Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.
Targeted Nanocarriers For The Administration Of Immunosuppressive Agents
Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
Lincoln Elementary School Salt Lake City UT 1949-1955, Westside Elementary School Springville UT 1955-1956, Springville Junior High School Springville UT 1956-1959