Carl R Gilbert

US Patent:

6774116, Aug 10, 2004

Filed:

Jan 31, 2002

Appl. No.:

10/066306

Inventors:

Carl W. Gilbert - Powder Springs GA
Eleanor B. McGowan - Smyrna GA
Kirby S. Black - Acworth GA
T. Gregory P. Harper - Stockton CA

Assignee:

Cryolife, Inc. - Kennesaw GA

International Classification:

A61K 31704

US Classification:

514 34, 514396, 514529, 51425212, 514785, 514568, 514554, 514614, 514613, 564164, 564167, 560 45, 548542, 544358

Abstract:

A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically withdrawing groups to modify the cinnamate moietys electric properties as well as photo reactivities for the purpose of achieving a proper hydrolysis rate of the acyl bond between the biologically active molecule moiety and the cinnamic acid backbone. The biologically active molecule can be any biologically active agent or diagnostic, for example, a chemotherapeutic such as a paclitaxel, campotothecin, doxorubicin, amethopterin, etoposide, or fluconazole. The prodrug composition can be modified to add a carrier moiety on the prodrug composition for targeting or to facilitate uptake of the drug. The prodrug compositions can be activated with an energy source to release the drug at the desired site.

US Patent:

7157458, Jan 2, 2007

Filed:

Jan 31, 2002

Appl. No.:

10/066323

Inventors:

Carl W. Gilbert - Powder Springs GA, US
Eleanor B. McGowan - Smyrna GA, US
Kirby S. Black - Acworth GA, US
T. Gregory P. Harper - Stockton CA, US

Assignee:

Cryolife, Inc. - Kennesaw GA

International Classification:

A61K 31/50
A61K 31/44
A61K 31/165
C07D 295/00
C07D 213/55

US Classification:

514247, 514277, 514461, 514532, 514617, 544358, 546341, 549499, 560104

Abstract:

Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:.

US Patent:

7449315, Nov 11, 2008

Filed:

Mar 30, 2007

Appl. No.:

11/694023

Inventors:

Carl W. Gilbert - Powder Springs GA, US
Eleanor B. McGowan - Smyrna GA, US
Kirby S. Black - Acworth GA, US
T. Gregory P. Harper - Stockton CA, US

Assignee:

Cryolife, Inc. - Kennesaw GA

International Classification:

C12N 9/00
A61K 47/00
A61K 31/704
A61K 31/495
C07C 57/44

US Classification:

435183, 514 34, 514396, 514529, 51425212, 514773, 514785, 514568, 514554, 514613, 514614, 564164, 564167, 560 45, 548542, 544358

Abstract:

Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:.

US Patent:

20060106204, May 18, 2006

Filed:

Dec 30, 2005

Appl. No.:

11/324053

Inventors:

Carl Gilbert - Powder Springs GA, US
Eleanor McGowan - Smyrna GA, US
Kirby Black - Acworth GA, US

International Classification:

C07K 16/46
C07K 14/78

US Classification:

530391100, 530409000

Abstract:

Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:

US Patent:

59519746, Sep 14, 1999

Filed:

Dec 19, 1997

Appl. No.:

8/994622

Inventors:

Carl W. Gilbert - Powder Springs GA
Myung-ok Park-Cho - Seoul, KR

Assignee:

Enzon, Inc. - Piscataway NJ

International Classification:

A61K 3821
C07K 1113
C07K 1456

US Classification:

424 857

Abstract:

Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for preparing the conjugates. The process includes contacting an alpha interferon with a succinimidyl carbonate-activated substantially non-antigenic polymer at a pH which is sufficient to facilitate covalent attachment of the polymer on a histidine of the alpha interferon.

US Patent:

60428228, Mar 28, 2000

Filed:

Apr 6, 1999

Appl. No.:

9/287476

Inventors:

Carl W. Gilbert - Powder Springs GA
Myung-ok Park-Cho - Seoul, KR

Assignee:

Enzon, Inc. - Piscataway NJ

International Classification:

A61K 3821
C07K 1113
C07K 1456

US Classification:

424 857

Abstract:

Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for preparing the conjugates. The process includes contacting an alpha interferon with a succinimidyl carbonate-activated substantially non-antigenic polymer at a pH which is sufficient to facilitate covalent attachment of the polymer on a histidine of the alpha interferon.

Address:

2006 Ebbsfleet Dr, Cedar Park, TX 78613

VIN:

5GZER23717J131912

Make:

SATURN

Model:

OUTLOOK

Year:

2007