Carlos F Mateus

US Patent:

7497992, Mar 3, 2009

Filed:

May 8, 2003

Appl. No.:

10/434015

Inventors:

Brian T. Cunningham - Lexington MA, US
Peter Y. Li - Andover MA, US
Constance Chang-Hasnain - Palo Alto CA, US
Carlos Mateus - Albany CA, US

Assignee:

SRU Biosystems, Inc. - Woburn MA
The Regents of the University of California - Oakland CA

International Classification:

C12M 1/34
C12M 3/00
G01N 33/53
G01N 21/00

US Classification:

422 8205, 422 8211, 435 6, 435 71, 4352831, 4352871, 4352872, 25022723, 25022727, 25022728, 436164

Abstract:

An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor. Molecular binding on the surface of the biosensor is indicated by a shift in the peak wavelength value of reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.

US Patent:

20090269244, Oct 29, 2009

Filed:

Jan 22, 2009

Appl. No.:

12/321715

Inventors:

Brian T. Cunningham - Champaign IL, US
Peter Y. Li - Andover MA, US
Constance Chang-Hasnain - Palo Alto CA, US
Carlos Mateus - Albany CA, US

International Classification:

G01N 21/31

US Classification:

422 8211

Abstract:

An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor. Molecular binding on the surface of the biosensor is indicated in a shift in the peak wavelength value of the reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.