Carlos M Samour

US Patent:

6495124, Dec 17, 2002

Filed:

Feb 14, 2000

Appl. No.:

09/503715

Inventors:

Carlos M. Samour - Bedford MA

Assignee:

Macrochem Corporation - Lexington MA

International Classification:

A61K 600

US Classification:

424 61, 424401, 424404

Abstract:

A nail lacquer for the treatment or prevention of fungal infections, such as, onychomycosis, includes fungicidally effective amount of ciclopirox, econazole, or other antifungal agent in a compatible film-forming lacquer vehicle which includes a water-insoluble film-forming polymer; pentadecalactone, or similar cyclic lactone compound or derivative thereof, and volatile solvent. The pentadecalactone functions as a plasticizer for the film-forming polymer and as a penetration enhancer for the antifungal agent. The composition, when applied to the nails provides a hard, clear, water-resistant film containing the antifungal agent. The compositions are used for the treatment of onychomycosis.

US Patent:

20030082226, May 1, 2003

Filed:

May 6, 2002

Appl. No.:

10/138777

Inventors:

Carlos Samour - Bedford MA, US
Scott Krauser - Tyngsboro MA, US
Robert Gyurik - Exeter NH, US

International Classification:

A61K009/70

US Classification:

424/449000

Abstract:

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane-or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

US Patent:

20030232070, Dec 18, 2003

Filed:

Nov 12, 2002

Appl. No.:

10/291765

Inventors:

Carlos Samour - Bedford MA, US

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

A61K009/70
C08K005/15

US Classification:

424/443000, 524/107000

Abstract:

A nail lacquer for the treatment or prevention of fungal infections, such as, onychomycosis, includes fungicidally effective amount of ciclopirox, econazole, or other antifungal agent in a compatible film-forming lacquer vehicle which includes a water-insoluble film-forming polymer; pentadecalactone, or similar cyclic lactone compound or derivative thereof, and volatile solvent. The pentadecalactone functions as a plasticizer for the film-forming polymer and as a penetration enhancer for the antifungal agent. The composition, when applied to the nails provides a hard, clear, water-resistant film containing the antifungal agent. The compositions are used for the treatment of onychomycosis.

US Patent:

20070134308, Jun 14, 2007

Filed:

Jul 5, 2006

Appl. No.:

11/480570

Inventors:

Carlos Samour - Bedford MA, US
Scott Krauser - Tyngsboro MA, US
Robert Gyurik - Exeter NH, US

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

A61K 31/192
A61F 13/02

US Classification:

424448000, 514569000

Abstract:

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

US Patent:

40296580, Jun 14, 1977

Filed:

Jun 2, 1975

Appl. No.:

5/582685

Inventors:

Carlos M. Samour - Wellesley Hills MA

Assignee:

The Kendall Company - Walpole MA

International Classification:

C07D29500

US Classification:

2602471E

Abstract:

A novel class of monomeric emulsion stabilizers is prepared by reacting certain quaternary ammonium halides with anionic surfactants. In polymerization reactions these stabilizers become a part of the polymer molecule, which is thereby self-stabilized in aqueous dispersion.

US Patent:

39364925, Feb 3, 1976

Filed:

Aug 9, 1974

Appl. No.:

5/496320

Inventors:

Carlos M. Samour - Wellesley Hills MA
Mildred C. Richards - Wakefield MA

Assignee:

The Kendall Company - Walpole MA

International Classification:

C07C 8730

US Classification:

260482R

Abstract:

A novel class of monomeric emulsion stabilizers consists of certain types of ethylenically-unsaturated radicals covalently linked to a quaternary nitrogen atom which in turn is covalently linked to a lipophilic radical. Such monomers will polymerize with other ethylenically-unsaturated radicals forming self-stabilized, surfactant-free polymeric dispersions.

US Patent:

40511588, Sep 27, 1977

Filed:

Dec 11, 1975

Appl. No.:

5/640110

Inventors:

Carlos M. Samour - Wellesley MA
Mildred C. Richards - Wakefield MA

Assignee:

The Kendall Company - Boston MA

International Classification:

C07C10124

US Classification:

2604045

Abstract:

Quaternary ammonium salts having a lipophilic group covalently linked to the quaternary nitrogen through hydroxysuccinyloxy or hydroxysuccinylamino radicals are disclosed. These quaternary ammonium salts are useful as monomeric emulsion stabilizers.

US Patent:

55277977, Jun 18, 1996

Filed:

Aug 20, 1993

Appl. No.:

8/109599

Inventors:

Solomon R. Eisenberg - Newton MA
Carlos M. Samour - Newport RI

Assignee:

Macrochem Corporation - Lexington MA
The Trustees of Boston University - Boston MA

International Classification:

A61K 31535
A61K 3117
A61K 31045

US Classification:

5142312

Abstract:

New and improved method for the transdermal administration of agents is provided utilizing iontophoresis in conjunction with a water-insoluble, stratum corneum-lipid modifier. The lipid modifier may be used prior to iontophoresis or simultaneously therewith. The lipid modifier may be selected from a wide variety of moieties of the general formula R--X where R is a C. sub. 5 to C. sub. 28 alkyl or unsaturated alkyl and X is a member of the following: 1,3-dioxane; 1,3-dioxolane; lactam; morpholine; --COOH; --OH; --COOR'; --C--N(R'). sub. 2 ; cyclo ethylene and propylene carbonates; --CONH. sub. 2 ; --(CH. sub. 2 --CH. sub. 2 O). sub. n H; ##STR1## acetals, and hemiacetals; and wherein R' is lower alkyl (e. g. , C. sub. 1 to C. sub. 3) and n is an integer of from 1 to 20. Optionally there may be present a polar, water-soluble chemical compound from the group of alcohols, glycols, lactams, dioxolanes, esters, ureas, morpholine and the like.