Carol J Morris

US Patent:

6827966, Dec 7, 2004

Filed:

May 22, 2002

Appl. No.:

10/153063

Inventors:

Yongxing Qiu - Duluth GA
Fiona Patricia Carney - Atlanta GA
Nichola Kotov - Stillwater OK
John Martin Lally - Lilburn GA
Carol Ann Morris - Duluth GA
Lynn Cook Winterton - Alpharetta GA

Assignee:

Novartis AG - Basel

International Classification:

B05D 300

US Classification:

427 224, 427 21, 427 231, 427162, 427164, 427402, 4274071, 4274121, 427414, 427415, 427421, 4274301, 4273722, 4273855

Abstract:

The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

US Patent:

7244394, Jul 17, 2007

Filed:

Sep 3, 2003

Appl. No.:

10/654196

Inventors:

Fiona Patricia Carney - Atlanta GA, US
Jennifer Dawn Lane - Stone Mountain GA, US
Carol Ann Morris - Duluth GA, US

Assignee:

Novartis AG - Basel

International Classification:

G01N 21/00
G01N 31/22
C08F 16/06
C08F 116/06
C08F 216/06
A61M 35/00

US Classification:

422 58, 422 56, 422 57, 521141, 604294

Abstract:

The invention, in one aspect, provides a strip for tear collection. The strip has a first end and an opposite second end and preferably has substantially uniform cross-sections from the first end to the second end. The strip is made of a hydrogel material in substantially dry state. The strip is characterized by having a substantially uniform swelling along the hydrogel strip from the first end to the second end when fully wicked by a tear fluid and by having a correlation between the volume of tear uptake by said strip and the length of the wicked end portion of said strip. A strip of the invention is useful for assay of an analyte of interest in a tear fluid. The invention also provides a method and kits for assaying an analyte of interest (e. g. , lactoferrin, glucose, herpes simplex virus, hormones, etc. ).

US Patent:

7402318, Jul 22, 2008

Filed:

Nov 4, 2002

Appl. No.:

10/287091

Inventors:

Carol Ann Morris - Duluth GA, US
Manal M. Gabriel - Marietta GA, US
Yongxing Qiu - Duluth GA, US
Lynn Cook Winterton - Alpharetta GA, US
John Martin Lally - Lilburn GA, US
Marcia Kay Ash - Snellville GA, US
Fiona Patricia Carney - Atlanta GA, US
Courtney Flem Morgan - Alpharetta GA, US

Assignee:

Novartis AG - Basel

International Classification:

A61F 13/00

US Classification:

424422, 424400, 514772

Abstract:

The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

US Patent:

7429462, Sep 30, 2008

Filed:

Feb 15, 2007

Appl. No.:

11/706809

Inventors:

Carol Ann Morris - Duluth GA, US
Fiona Patricia Carney - Atlanta GA, US
Jennifer Dawn Lane - Stone Mountain GA, US

Assignee:

Novartis AG - Basel

International Classification:

C12Q 1/54

US Classification:

435 14

Abstract:

The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.

US Patent:

7666461, Feb 23, 2010

Filed:

Oct 20, 2004

Appl. No.:

10/969280

Inventors:

Yongxing Qiu - Duluth GA, US
Fiona Patricia Carney - Atlanta GA, US
Nichola Kotov - Stillwater OK, US
John Martin Lally - Lilburn GA, US
Carol Ann Morris - Duluth GA, US

Assignee:

Novartis AG - Basel

International Classification:

B05D 3/00
G02C 7/04
A61F 2/14

US Classification:

427 21, 427 214, 427 224, 424422, 424425, 424426, 351159, 351160 R

Abstract:

The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

US Patent:

8172395, May 8, 2012

Filed:

Nov 25, 2003

Appl. No.:

10/722256

Inventors:

Fiona Patricia Carney - Atlanta GA, US
Manal M. Gabriel - Marietta GA, US
Carol Ann Morris - Duluth GA, US
John Martin Lally - Lilburn GA, US

Assignee:

Novartis AG - Basel

International Classification:

G02C 7/02

US Classification:

351159, 264 17, 264 26

Abstract:

The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.

US Patent:

20040181167, Sep 16, 2004

Filed:

Mar 10, 2004

Appl. No.:

10/797678

Inventors:

Fiona Carney - Atlanta GA, US
Carol Morris - Duluth GA, US

International Classification:

A61B010/00
G01N033/53

US Classification:

600/551000, 435/007100

Abstract:

The invention provides methods and kits for monitoring the status of women's health, including HRT monitoring and determination or diagnosis of ovulation, contraception, pregnancy, menopause, polycystic ovarian disease, and female sexual dysfunction. The method comprises the steps of: (a) collecting a tear fluid from a female human; (b) determining the tear concentration of at least one hormone of relevance to female fertility, sexual differentiation or sexual dysfunction in a female human, wherein the tear concentration is diagnostics of the status of women's health.

US Patent:

20040181172, Sep 16, 2004

Filed:

Mar 10, 2004

Appl. No.:

10/797707

Inventors:

Fiona Carney - Atlanta GA, US
Carol Morris - Duluth GA, US
Yongxing Qiu - Duluth GA, US

International Classification:

A61B005/00
G01N033/53

US Classification:

600/573000, 435/007100

Abstract:

The present invention provides a contact lens, preferably a daily disposable contact lens, which can be used to collect one or more analytes of interest in a tear fluid, and in turn, determine the physiological state or health of an individual.