Carol A Reiss

US Patent:

20110014228, Jan 20, 2011

Filed:

Jun 15, 2010

Appl. No.:

12/816024

Inventors:

Carol Shoshkes REISS - New York NY, US
James M. MILLER - New York NY, US

Assignee:

NEW YORK UNIVERSITY - New York NY

International Classification:

A61K 39/12
C12N 7/01
C07H 21/02
C12N 5/10
A61K 35/76
A61P 35/00
A61P 37/04

US Classification:

4242041, 4352351, 536 235, 435325, 536 2372, 424 936

Abstract:

The present invention relates to recombinant replicable viral vectors and viruses which are modified with IL23. This IL23 modified virus is highly immunogenic and attenuated for neurotropic pathology found in the wild type viruses. These viruses and vectors can be used for treatment of a variety of cancers and for vaccination against many viral, bacterial, or parasitic diseases.

US Patent:

7012061, Mar 14, 2006

Filed:

Oct 19, 1999

Appl. No.:

09/807826

Inventors:

Carol Shoshkes Reiss - New York NY, US
Takaishi Komatsu - Whitestone NY, US

Assignee:

New York University - New York NY

International Classification:

A01N 37/18

US Classification:

514 2

Abstract:

The present invention relates to a method for regulating the permeability of the blood brain barrier by administering a NOS-3 inhibitor to reduce the increased permeability of the blood brain barrier caused by a pathological condition or by administering a NOS-3 activator or nitric oxide donor to increase the permeability of the blood brain barrier. By increasing the permeability of the blood barrier, a therapeutic or diagnostic compound can be delivered across this barrier into the central nervous system.