P. Jeffrey Conn - Brentwood TN, US Alice L. Rodriguez - Nashville TN, US Carrie K. Jones - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A61K 31/497 C07D 239/42
US Classification:
5142521, 514256
Abstract:
Provided is a method of treating conditions and disorders for which full mGluR5 antagonists are potentially effective, such as, e. g. , anxiety, epilepsy, schizophrenia and other psychotic disorders, Parkinson's disease, addictive disorders, and the like in a subject in need of such treatment, comprising administration to such subject of a therapeutically effective amount of a partial, non-competitive mGluR5 antagonist compound of the invention. Specific examples of partial MgluR5 antagonists provided include those compounds having the formula:.
Bicyclic Mglur5 Positive Allosteric Modulators And Methods Of Making And Using Same
P. Jeffrey Conn - Brentwood TN, US Craig W. Lindsley - Brentwood TN, US Charles David Weaver - Franklin TN, US Alice L. Rodriguez - Nashville TN, US Colleen M. Niswender - Brentwood TN, US Carrie K. Jones - Nashville TN, US Richard Williams - Nashville TN, US
In one aspect, the invention relates to bicyclic MGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Alkylsulfonyl-2,3-Dihydrospiro[Indene-1,4′-Piperidine] Analogs As Glyt1 Inhibitors, Methods For Making Same, And Use Of Same In Treating Psychiatric Disorders
Craig W. Lindsley - Brentwood TN, US P. Jeffrey Conn - Brentwood TN, US Richard Williams - Bangor, GB Carrie K. Jones - Nashville TN, US Douglas J. Sheffler - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C07D 401/00
US Classification:
546 17
Abstract:
In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Sulfonyl-Piperidin-4-Yl Methylamine Amide Analogs As Glyt1 Inhibitors, Methods For Making Same, And Use Of Same In Treating Psychiatric Disorders
Craig W. Lindsley - Brentwood TN, US P. Jeffrey Conn - Brentwood TN, US Richard Williams - Bangor North Down, GB Carrie K. Jones - Nashville TN, US Douglas J. Sheffler - Nashville TN, US
In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
3.1.0 Bicyclic Glyt1 Inhibitors And Methods Of Making And Using Same
Craig W. Lindsley - Brentwood TN, US P. Jeffrey Conn - Brentwood TN, US Richard Williams - Bangor, GB Carrie K. Jones - Nashville TN, US Douglas J. Sheffler - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A61K 31/44 C07D 403/02
US Classification:
514339, 514398, 5483147, 5462767
Abstract:
In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Substituted Phenylamine Carboxamide Analogs As Mglur5 Negative Allosteric Modulators And Methods Of Making And Using The Same
P. Jeffrey Conn - Brentwood TN, US Craig W. Lindsley - Brentwood TN, US Kyle A. Emmitte - Spring Hill TN, US Charles David Weaver - Franklin TN, US Alice L. Rodriguez - Nashville TN, US Andrew S. Felts - Nashville TN, US Carrie K. Jones - Nashville TN, US Brittney S. Bates - Nashville TN, US Brian A. Chauder - Smyrna TN, US
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Substituted Heteroarylamine Carboxamide Analogs As Mglur5 Negative Allosteric Modulators And Methods Of Making And Using The Same
P. Jeffrey Conn - Brentwood TN, US Craig W. Lindsley - Brentwood TN, US Kyle A. Emmitte - Spring Hill TN, US Charles David Weaver - Franklin TN, US Alice L. Rodriguez - Nashville TN, US Andrew S. Felts - Nashville TN, US Carrie K. Jones - Nashville TN, US Brittney S. Bates - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A01N 37/30 A61K 31/205
US Classification:
51425505, 544295
Abstract:
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Bicyclic Triazole And Pyrazole Lactams As Allosteric Modulators Of Mglur5 Receptors
P. Jeffrey Conn - Brentwood TN, US Craig W. Lindsley - Brentwood TN, US Shaun R. Stauffer - Brentwood TN, US José Manuel Bartolomé-Nebreda - Toledo, ES Susana Conde-Ceide - Toledo, ES Gregor James MacDonald - Beerse, BE Han Min Tong - Toledo, ES Carrie K. Jones - Nashville TN, US Manuel Jesús Alcázar-Vaca - Toledo, ES José Ignacio Andrés-Gil - Toledo, ES Chrysa Malosh - Nashville TN, US
In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Pite Duncan, LLP Phoenix, AZ Aug 2010 to Jul 2013 Attorney / TrusteeLaw Office of Carrie Thompson Jones, PLLC Phoenix, AZ Jan 2010 to Aug 2010 Owner and ManagerHowarth & Smith Los Angeles, CA May 2008 to Jul 2008 Summer AssociateBueler Jones, LLP Chandler, AZ May 2007 to Jul 2007 Law ClerkLittle Peanut Products Chandler, AZ Jul 2001 to Aug 2006 OwnerThe Pepsi Bottling Group Phoenix, AZ May 1999 to Mar 2001 Key Account Manager - Education ChannelUnitech Enterprises Hefei, CN Sep 1997 to Dec 1998 Assistant General ManagerBank of America Mesa, AZ 1993 to 1995 Senior Financial Services Representative
Education:
Sandra Day O'Connor College of Law May 2009 Juris DoctorateArizona State University Tempe, AZ 2007 to 2008 International Law Students AssociationKennedy Center for International Studies Apr 1996 Bachelor of ArtsBrigham Young University Provo, UT 1996 International RelationsArizona State University 1993
CustomInk Charlottesville, VA Feb 2014 to May 2014 Sales AssociateField Organizer, State Senate Campaign Sterling, VA Nov 2013 to Dec 2013Field Organizer, House of Delegates Campaign Ashburn, VA Sep 2013 to Nov 2013UNC Charlotte Charlotte, NC Aug 2012 to May 2013 Full-Time LecturerUniversity of North Carolina Charlotte Charlotte, NC Mar 2011 to May 2011 Research AssistantY? Morrissey New York, NY Feb 2006 to May 2008 Account ExecutivePow Wow New York, NY Jan 2004 to Jan 2006 Account ExecutiveKay Celine Los Angeles, CA Feb 2002 to Jan 2004 National Sales Manager
Education:
University of North Carolina Charlotte, NC Jun 2012 Master of Arts in Religious StudiesUniversity of North Carolina Charlotte, NC Aug 2008 to May 2010 Bachelor of Arts in Summa
PATIENT ENGAGEMENT ADVISORS (PEA) Birmingham, AL 2012 to 2013 Director of EngagementMEDSEEK INC Birmingham, AL 2011 to 2012 Implementation and Training SpecialistMCKESSON CORP Birmingham, AL 2006 to 2011 Project ManagerHEALTHSOUTH CORP Birmingham, AL 2001 to 2006 Regional Marketing CoordinatorGIBSON GUITAR CORP Nashville, TN 1999 to 2000 Entertainment Relations RepresentativeREUNION RECORDS Nashville, TN 1992 to 1998 Artist and Repertoire (A&R) Coordinator
Education:
BELMONT UNIVERSITY Nashville, TN 1996 Bachelor of Business Administration in Music Business
Oregon Health & Science University / Knight Cancer Institute
Feb 2012 to 2000Digital Domain Venice, CA Jun 2010 to Aug 2011 Executive Coordinator / Head of Special ProjectsPilgrim Films & Television Sherman Oaks, CA Mar 2009 to Apr 2010 Operations ManagerHard Rock Hotel & Casino Los Angeles, CA Apr 2003 to Mar 2004 Executive Assistant to Peter Morton, Chairman and OwnerJerry Bruckheimer Films Santa Monica, CA Aug 2001 to Apr 2003 Events & Special Projects ExecutiveAmerican Golf Corporation Santa Monica, CA Aug 2000 to Aug 2001 Senior Executive Assistant
May 2012 to 2000 BusHomeSafe of Sumner, Wilson and Robertson County
2011 to 2000 VolunteerNational Entertainment Network Hendersonville, TN 2010 to 2011 CollectorNational Entertainment Network Goodlettsville, TN 2007 to Oct 2010 Field Service RepresentativeLebanon-Wilson County Chamber of Commerce Lebanon, TN 2010 to 2010 VolunteerSumner County Sheriff Department Gallatin, TN 2005 to 2007 Correctional OfficerH&R Block Lebanon, TN 2004 to 2005 Tax AssociateSpace Business Forms & Imaging, Inc Lodi, CA 2003 to 2004 Financial Administrator/Office ManagerR&S Architectural Products, Inc West Sacramento, CA 1999 to 2003 Office ManagerWal-Mart Stores, Inc Stockton, CA 1990 to 1998 Department Manager
Education:
Tennessee Tech Center @ Hartsville Hartsville, TN 2010 to 2011 Certificate in Medical Coding and Health InformationVolunteer State Community College 2004 to 2007
Feb 2011 to 2000 Clinic Coordinator II, Infusion ServicesInfusion Partners Birmingham, AL Apr 2007 to Feb 2011 Account Executive/Nurse ClinicianChildren's of Alabama Birmingham, AL Mar 1993 to Feb 2011 RN II in PICU and for Nursing ResourcesSt. Francis Memorial Hospital San Francisco, CA Jul 2001 to Apr 2007 Staff RN in ICB/ICUUniversity of Alabama Hospital at Birmingham Birmingham, AL 1992 to 2005 Staff RN/Coordinator/Trainer/Instruc...Therapeutic Innovations Roanoke, VA Jul 2000 to May 2001 Medical Sales Representative/Wound Care ConsultantGinsburg Dermatology Birmingham, AL Oct 1999 to Jul 2000 Administrative Clinical Nurse ManagerFlowers' Hospital Dothan, AL 1986 to 1992 Staff LPN/RN, MICU 3/6th Surgical/Pediatrics
Education:
The University of Alabama School of Education Tuscaloosa, AL 2010 to 2014 Doctorate in EducationCapstone College of Nursing at the University of Alabama Tuscaloosa, AL 2010 to 2013 Master's in Nursing Case ManagementThe University of Alabama Capstone College of Nursing Tuscaloosa, AL 1994 to 1996 Bachelor's in Nursing
Dr. Jones graduated from the Eastern Virginia Medical School Medical College in 1993. She works in Quincy, MA and 1 other location and specializes in Pediatrics and Adolescent Medicine. Dr. Jones is affiliated with South Shore Hospital.
Dr. Jones graduated from the University of New Mexico School of Medicine in 2011. She works in Santa Fe, NM and specializes in Family Medicine. Dr. Jones is affiliated with Presbyterian Hospital.
Dr. Jones graduated from the University of Texas Medical Branch at Galveston in 1998. She works in Denton, TX and specializes in Pediatrics. Dr. Jones is affiliated with Cook Childrens Medical Center and Texas Health Presbyterian Hospital Denton.
Legacy Medical GroupPediatric Development & Rehabilitation 2801 N Gantenbein Ave STE 2225, Portland, OR 97227 (503)4134505 (phone), (503)4134719 (fax)
Education:
Medical School Ohio State University College of Medicine Graduated: 2007
Languages:
English Spanish
Description:
Dr. Jones graduated from the Ohio State University College of Medicine in 2007. She works in Portland, OR and specializes in Family Medicine and Neurodevelopmental Disabilities. Dr. Jones is affiliated with Legacy Good Samaritan Hospital & Medical Center, Legacy Meridian Park Hospital and Randall Childrens Hospital At Legacy Emanuel.
Illinois CancercareIllinois Cancer Care 8940 N Wood Sage Rd, Peoria, IL 61615 (309)2433000 (phone), (309)2433054 (fax)
Illinois CancercareIllinois Cancer Care 603 S 13 St, Pekin, IL 61554 (309)3530214 (phone), (309)3471116 (fax)
Languages:
English Korean
Description:
Ms. Jones works in Pekin, IL and 1 other location and specializes in Hematology/Oncology. Ms. Jones is affiliated with OSF Saint Francis Medical Center, Pekin Hospital, UnityPoint Health Methodist Hospital and Unitypoint Health Proctor Hospital.
Mercy Hospital Of Buffalo Cardiology 565 Abbott Rd, Buffalo, NY 14220 (716)8282392 (phone), (716)8343901 (fax)
Languages:
English
Description:
Ms. Jones works in Buffalo, NY and specializes in Cardiovascular Disease. Ms. Jones is affiliated with Mercy Hospital Of Buffalo and Sisters Of Charity Hospital Saint Joseph Campus.
Atlanta, GeorgiaManaging Partner at Alchemy 8 Entertainment LLC Ms. Jones began her media and marketing career 17 years ago developing shows for Fortune 500 companies, which allowed them an opportunity to air their new... Ms. Jones began her media and marketing career 17 years ago developing shows for Fortune 500 companies, which allowed them an opportunity to air their new technology, flag ship products or services on Discovery. She has a diverse background from ownership for 12 years in her Distributor Marketing...
ATI Industrial Technologies Currently working for ATI Industrial Automation we make robotic equipment for automotive and medical applications.
This is a small company it reminds me of... Currently working for ATI Industrial Automation we make robotic equipment for automotive and medical applications.
This is a small company it reminds me of Parigain, I enjoy working here.
Hours after Snyder unveiled his budget Thursday, Carrie Jones, director of the Michigan Film Office, sent an e-mail to a few movie industry insiders acknowledging that the plan must get through the state House and Senate. But, she added, "Our office will be following the governor's guidelines pendin