Chantelle E Domingue

US Patent:

20200408737, Dec 31, 2020

Filed:

Apr 20, 2017

Appl. No.:

16/494398

Inventors:

- Spring TX, US
Matthew David SMITH - Corvallis OR, US
Masoud ZAVAREHI - Corvallis OR, US
Joshua M. YU - Corvallis OR, US
Chantelle DOMINGUE - Corvallis OR, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

G01N 33/49
B01L 3/00
G01N 33/86

Abstract:

A microfluidic coagulation analysis method includes introducing a fluid sample into a measurement device including a pinch point that includes a microfluidic channel of substantially consistent width and height connecting a slot and a chamber. The at least one pinch point permits passage of the fluid sample from the slot to the chamber. The method further includes measuring, with a sensor in or near the pinch point, transits of individual cells in the sample passing through the at least one pinch point, and computing, at least in part with a processor, at least one metric indicative of a time period during which the flow of the sample transitions from substantially fluid flow to substantial cessation of flow.

US Patent:

20200197936, Jun 25, 2020

Filed:

Jul 28, 2017

Appl. No.:

16/619508

Inventors:

- Spring TX, US
Matthew David SMITH - Corvallis OR, US
Jeremy SELLS - Corvallis OR, US
George H. CORRIGAN - Corvallis OR, US
Michael W. CUMBIE - Corvallis OR, US
Chantelle DOMINGUE - Corvallis OR, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

B01L 3/00
B01L 7/00
C12Q 1/6876
G01N 21/64

Abstract:

A method may include maintaining a sample comprising an ionic species and an optical indicator at an elevated temperature above 25 C. on a semi-conductive microfluidic die during an incubation period, intermittently interrogating the sample with an interrogating light during the incubation period and sensing a response of the sample to the interrogating light, wherein the sample is interrogated with the interrogating light only during those times at which the sample is being sensed.

US Patent:

20200139366, May 7, 2020

Filed:

Oct 7, 2016

Appl. No.:

16/319702

Inventors:

- Spring TX, US
Chantelle DOMINGUE - Corvallis OR, US
Tod WOODFORD - Corvallis OR, US
Matthew David SMITH - Corvallis OR, US
Rachael M. WHITE - Corvallis OR, US
Joshua M. YU - Corvallis OR, US
Hilary ELY - Corvallis OR, US
Jeremy SELLS - Corvallis OR, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

B01L 3/00

Abstract:

The present disclosure is drawn to microfluidic chips. The microfluidic chips can include an inflexible material having an elastic modulus of 0.1 gigapascals (GPa) to 450 GPa. A microfluidic channel can be formed within the inflexible material and can connect an inlet and an outlet. A working electrode can be associated with the microfluidic channel and can have a surface area of 1 μmto 60,000 μmwithin the microfluidic channel. A bubble support structure can also be formed within the microfluidic channel such that the working electrode is positioned to electrolytically generate a bubble that becomes associated with the bubble support structure.

US Patent:

20200088715, Mar 19, 2020

Filed:

Apr 20, 2017

Appl. No.:

16/494473

Inventors:

- Spring TX, US
Rachel M. WHITE - Corvallis OR, US
Tod WOODFORD - Corvallis OR, US
Chantelle DOMINGUE - Corvallis OR, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

G01N 33/49
G01N 33/86

Abstract:

A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.

US Patent:

20200088716, Mar 19, 2020

Filed:

Apr 20, 2017

Appl. No.:

16/494528

Inventors:

- Spring TX, US
Tod WOODFORD - Corvallis OR, US
Chantelle DOMINGUE - Corvallis OR, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

G01N 33/49
G01N 33/543
G01N 33/86
B01L 3/00
C12M 1/34

Abstract:

A microfluidic blood coagulation testing die includes a substrate, a slot defined in the substrate permitting entry of a blood sample, a chamber defined in the substrate that collects red blood cells from the blood sample, and a microfluidic path that provides a fluid connection from the slot to the chamber. The microfluidic path includes a channel, an inlet disposed at one end of the channel and an outlet disposed at the other end of the channel.

US Patent:

20200041396, Feb 6, 2020

Filed:

Feb 10, 2017

Appl. No.:

16/476187

Inventors:

- Spring TX, US
Adam Higgins - Corvallis OR, US
Chantelle Domingue - Palo Alto CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

G01N 11/06

Abstract:

The viscosity of a fluid may be determined using a flow rate determination. The flow rate may be determined based on fluid presence determinations within a capillary channel. Also, a temperature of an environment surrounding a capillary channel may be determined and signals may be transmitted to a thermal element responsive to the determined temperature.

US Patent:

20190285564, Sep 19, 2019

Filed:

Oct 5, 2016

Appl. No.:

16/319026

Inventors:

- Spring TX, US
Chantelle DOMINGUE - Corvallis OR, US
Sadiq BENGALI - Corvallis OR, US

Assignee:

Hewlett-Packard Development Company, L.P. - Spring TX

International Classification:

G01N 27/12

Abstract:

The present disclosure is drawn to an insulated sensor including a silicon substrate with active circuitry on a surface thereof, an electrode disposed on the silicon substrate, a passivation layer having a thickness from greater than 500 Angstroms to 3,000 Angstroms disposed on the active circuitry, and an electrode insulating layer having a thickness from 10 Angstroms to 500 Angstroms disposed on the electrode.

US Patent:

20190151848, May 23, 2019

Filed:

Jul 26, 2016

Appl. No.:

16/099658

Inventors:

- Houston TX, US
Manish GIRI - Corvallis OR, US
Chantelle DOMINGUE - Corvallis OR, US
Kenneth WARD - Corvallis OR, US
Christie DUDENHOEFER - Corvallis OR, US
Matthew David SMITH - Corvallis OR, US
Joshua M. YU - Corvallis OR, US
Hilary ELY - Corvallis OR, US

International Classification:

B01L 3/00
G01N 15/10
G01N 15/14

Abstract:

According to an example, a microfluidic apparatus may include a fluid slot, a foyer in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer, a sensor to detect a presence of a particle of interest in a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to receive information from the sensor, determine, from the received information, whether a particle of interest has passed through the channel, and control the actuator to expel fluid in the foyer through the nozzle based upon the determination.