Charles R Buck

US Patent:

20050262577, Nov 24, 2005

Filed:

Sep 23, 2003

Appl. No.:

10/528031

Inventors:

Christian Guelly - Graz, AT
Charles Buck - West Lafayette IN, US
Kurt Zatloukal - Graz, AT

International Classification:

A01K067/00
C12Q001/68
C07H021/04
C12N015/09
C07K014/82
C07K016/30

US Classification:

800008000, 435006000, 435069100, 435320100, 435325000, 530350000, 530388800, 536023500

Abstract:

The invention relates to polypeptides and nucleic acids encoding these and to their use for the diagnosis, prevention and/or treatment of liver disorders and neoplastic disorders, especially cancer of the liver and other epithelial tissues, benign liver neoplasms such as adenoma and other proliferative liver disorders such as focal nodular hyperplasia (FNH) and cirrhosis. The invention further relates to methods of diagnosing and treating these disorders.

US Patent:

20070161609, Jul 12, 2007

Filed:

Jan 10, 2006

Appl. No.:

11/328247

Inventors:

Charles Buck - West Lafayette IN, US
Helmut Denk - Graz, AT
Eleonore Frohlich - Graz, AT
Birgit Gutmann - Graz, AT
Peter Hecht - Graz, AT
Ivica Kvietikova - Graz, AT
Marcus Otte - Graz, AT
Gottfried Schatz - Reinach, CH
Cornelia Stumptner - Graz, AT
Lionel Wightman - Vienna, AT
Kurt Zatloukal - Graz, AT

International Classification:

A61K 31/66
A61K 31/41

US Classification:

514130000, 514359000

Abstract:

The present invention relates to the method of treatment or prophylaxis of patients with drug-induced liver diseases which comprises administering to the patient in need thereof a therapeutically effective amount of a mitochondrially targeted antioxidant compound e.g. derivatives of vitamin E, coenzyme Qor a glutathione peroxidase mimetic. The present invention also relates to pharmaceutical compositions containing the antioxidant(s) intended for such use.

US Patent:

20070225255, Sep 27, 2007

Filed:

Jul 12, 2005

Appl. No.:

11/632149

Inventors:

Eleonore Frohlich - Graz, DE
Ivica Kvietikova - Graz, AT
Kurt Zatloukal - Graz, AT
Gottfried Schatz - Reinach, CH
Helmut Denk - Graz, AT
Cornelia Stumptner - Graz, AT
Charles Buck - West Lafayette IN, US

International Classification:

A61K 31/66

US Classification:

514075000

Abstract:

The present invention relates to the use of a mitochondrially targeted antioxidant, e.g. derivatives of vitamin E, coenzyme Qor a glutathione peroxidase mimetic, in the treatment and prevention of liver diseases and/or epithelial cancers. The present invention also relates to pharmaceutical compositions containing the antioxidant(s) intended for such use. Furthermore the invention relates to the manufacture of medicaments containing the antioxidant(s) useful for such prevention and treatment.

US Patent:

20130059291, Mar 7, 2013

Filed:

Aug 16, 2012

Appl. No.:

13/587087

Inventors:

Richard J. Kuhn - West Lafayette IN, US
Catherine Paige Riley - Couer d'alene ID, US
Charles Buck - Coeur d'Alene ID, US

Assignee:

PURDUE RESEARCH FOUNDATION - West Lafayette IN

International Classification:

G01N 27/62

US Classification:

435 5

Abstract:

The invention generally relates to compositions and methods for identifying dengue virus. In certain embodiments, the invention provides methods for identifying a dengue virus serotype that involve obtaining a sample comprising at least one dengue virus protein; digesting the protein to produce peptides; ionizing the peptides; detecting a parent and associated fragment ion of the peptides; and identifying the serotype based on results of the detecting step.