Jerome A. Grunstad - Inver Grove Heights MN, US Charles Buckner - Chapel Hill NC, US Cyan Godfrey - Chapel Hill NC, US Daniel Deaton - Apex NC, US Andrew J. Valentine - Raleigh NC, US Margaret F. Butler - Raleigh NC, US Thomas W. Ruckdeschel - Cary NC, US
Assignee:
Oriel Therapeutics, Inc. - Durham NC
International Classification:
2401
US Classification:
D24110
Apparatus And Method For Handling Fluids At Nano-Scale Rates
Gregory A. Votaw - Durham NC, US Charles A. Buckner - Chapel Hill NC, US Daniel M. Hartmann - East Lansing MI, US William Karsh - Belmont MA, US Frank Anthony Montefusco - Durham NC, US Joshua T. Nevill - El Cerrito CA, US Mehul Patel - Ambler PA, US David W. Wyrick - Durham NC, US Hugh C. Crenshaw - Durham NC, US
Assignee:
AB Sciex, LLC - Framingham MA
International Classification:
F04B 17/00
US Classification:
417415, 604152, 417 32
Abstract:
Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
Jerome A. Grunstad - Inver Grove Heights MN, US Charles Buckner - Chapel Hill NC, US Cyan Godfrey - Chapel Hill NC, US Daniel Deaton - Apex NC, US Andrew J. Valentine - Raleigh NC, US Margaret F. Butler - Raleigh NC, US Thomas W. Ruckdeschel - Cary NC, US
Charles Buckner - Durham NC, US John Mascho - Clayton NC, US
International Classification:
G01B003/22
US Classification:
033/833000
Abstract:
An apparatus for measuring the alignment of a valve sealed onto a canister comprises hollow lower and upper sections, a mounting platform, and a transducer. The upper and lower interior regions cooperatively define an inner chamber in which the mounting platform is disposed. The transducer is mounted to the upper section and includes a probe extending through the upper section and into the inner chamber. The apparatus is adapted for relative rotational movement between the mounting platform and the upper section. The transducer is responsive to linear translation of the probe and displays a human-readable indication of the alignment of a valve sealed in a canister as the probe moves around the circumference of the top surface of the valve.
System And Method For Check-Weighing The Content Of A Blister
Charles Buckner - Durham NC, US Milton Bynum - Lake Villa IL, US David Moody - Durham NC, US Michael Strong - Durham NC, US Thomas Wilson - Durham NC, US
International Classification:
B65D083/04 B65D085/42
US Classification:
206/538000
Abstract:
A system for check-weighing a metered dose powder inhaler blister comprises a guide () adapted to receive a blister strip () comprised of at least one blister, a punch () aligned with the guide () for receiving the at least one blister; an actuator () engaged with the punch () for driving the punch toward the blister strip (), whereby the blister () is punched from the blister strip; and a balance () adapted to receive the punched blister () for weighing the punched blister () and generating a punched blister weight for the at least one blister.
Metered Dose Inhaler Cleaning Method And Apparatus
Prashant P. Kakade - Sunnyville CA, US Patrick O'Hara - Madison NJ, US Charles A. Buckner - Chapel Hill NC, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61M 11/00
US Classification:
12820023, 12820312
Abstract:
A canister of pressurized medicament is removed from a metered dose inhaler actuation assembly and thereafter subjected to a cleaning firing to dislodge any material that can be built up on the interior of the canister's valve stem. During the cleaning firing, backpressure in the valve stem is reduced and/or eliminated by routing the resulting flow to atmosphere along an improved flow path. The improved flow path can be such that there are no constrictions less than about 75% of the size of the valve stem's outlet port. Thus, the backpressure experienced by the valve stem is greatly reduced versus that experienced during a normal dosing firing. As a result, the flow rate of medicament through the valve stem during the cleaning firing can be higher than during a normal dosing firing, allowing the built-up material to be dislodged during the cleaning firing.