Charles M Cantor

US Patent:

44734522, Sep 25, 1984

Filed:

Nov 18, 1982

Appl. No.:

6/442580

Inventors:

Charles R. Cantor - New York NY
David C. Schwartz - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

G01N 2726
G01N 2728

US Classification:

204180G

Abstract:

Disclosed are an apparatus for and a method of electrophoretically separating particles by electric fields which are transverse to each other, which alternate between respective high and low intensities out of phase with each other at a frequency related to the mass of the particles and which move the particles in an overall direction transverse to the respective directions of the fields. For separating large macromolecules, at least one of the fields preferably has an intensity gradient in a direction transverse to its own. The new arrangement makes it possible to: (1) separate particles (molecules) larger in size than those able to be separated with previously known techniques, (2) carry out separation at higher speed and at better resolution than is possible with previously known techniques, and (3) concurrently separate particles which differ greatly in mass (molecular weight).

US Patent:

46955488, Sep 22, 1987

Filed:

Sep 25, 1984

Appl. No.:

6/654641

Inventors:

Charles R. Cantor - New York NY
David C. Schwartz - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 1112

US Classification:

435179

Abstract:

Gel inserts comprising a solidified liquid such as agarose suitable for use in an electrophoretic method, lysed cells entrapped within a matrix formed by the solidified liquid and macromolecules such as DNA or intact chromosomes derived from the lysed cells may be advantageously used in electrophoretic separations. The gel inserts are placed directly in a suitable support medium and subjected to one or more electric fields to separate the macromolecules.

US Patent:

49083082, Mar 13, 1990

Filed:

Jun 19, 1985

Appl. No.:

6/746282

Inventors:

Lex H. T. Van der Ploeg - New York NY
Suzanne H. Giannini - New York NY
Charles R. Cantor - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12Q 168
C12Q 118
C12Q 104
C12Q 106

US Classification:

435 6

Abstract:

This invention concerns a method for identifying in vitro an animal-infective form of a parasitic protozoan which comprises recovering total mRNA from the protozoan and detecting in the mRNA so recovered the presence of a mRNA transcript encoding a heat shock protein associated with animal-infective parasitic protozoans, which transcript is present only in the animal-infective form of the protozoan, or quantitatively determining in the mRNA so recovered the number of a mRNA transcript encoding a heat shock protein associated with animal-infective parasitic protozoans, which transcript is present in increased number only in the animal-infective form of the parasitic protozoan. This invention also concerns a method for identifying an agent capable of blocking the formation of the animal-infective form of a parasitic protozoan.

US Patent:

48614483, Aug 29, 1989

Filed:

Sep 22, 1987

Appl. No.:

7/099535

Inventors:

Charles R. Cantor - New York NY
David C. Schwartz - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C25D 1300

US Classification:

2041828

Abstract:

Gel inserts comprising a solidified liquid such as agarose suitable for use in an electrophoretic method, lysed cells entrapped within a matrix formed by the solidified liquid and macromolecules such as DNA or intact chromosomes derived from the lysed cells may be advantageously used in electrophoretic separations. The gel inserts are placed directly in a suitable support medium and subjected to one or more electric fields to separate the macromolecules.

US Patent:

39369234, Feb 10, 1976

Filed:

Nov 5, 1974

Appl. No.:

5/521112

Inventors:

Charles E. Cantor - Englewood NJ

Assignee:

Textron Inc. - Providence RI

International Classification:

B29D 500

US Classification:

29408

Abstract:

Apparatus and method for installing a slide fastener with or without a slider and pull assembly to material wherein specially arranged and spaced pairs of pins pierce the adjacent edges of the carrier tapes of the slide fastener prior to the slide fastener being bonded to material.

US Patent:

48392936, Jun 13, 1989

Filed:

Feb 24, 1986

Appl. No.:

6/833324

Inventors:

Charles R. Cantor - New York NY
Richard Axel - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 1500
C12P 2100
C12P 2102
C07H 1512

US Classification:

435320

Abstract:

DNA which encodes the polypeptide streptavidin has been isolated as a fragment 2 kb in length derived from a restriction endonuclease digestion of the chromosomal DNA of Streptomyces avidinii. The nucleic acid sequence of the gene and the amino acid sequence of the polypeptide have been determined. A fused gene has been prepared which comprises the streptavidin gene fused to a gene encoding the human LDL receptor. Expression of the gene fusion results in a fused streptavidin-human LDL receptor polypeptide. Methods are provided for using the fused gene to produce labeled, chemically modified proteins in vivo and to isolate a protein knowing only the nucleotide sequence of the gene encoding the protein.

US Patent:

48683116, Sep 19, 1989

Filed:

Apr 2, 1988

Appl. No.:

6/847422

Inventors:

Wilma A. Saffran - Forest Hills NY
Richard L. Edelson - Westport CT
Francis P. Gasparro - Hamden CT
John T. Welsh - New York NY
Charles R. Cantor - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D51900

US Classification:

548303

Abstract:

The present invention provides a compound having the formula ##STR1## wherein Y is biotin or iminobiotin, X is CH. sub. 2, P is psoralen or a psoralen derivative, r is an integer equal to or greater than 2 and s is an integer equal to or greater than 1. The invention also provides a method for preparing a biotinylated psoralen or a biotinylated psoralen derivative. Further provided are methods for detecting, purifying, and isolating nucleic acids, and methods for delivering an iminobiotinylated psoralen to a cell.

US Patent:

20220404241, Dec 22, 2022

Filed:

Jun 21, 2022

Appl. No.:

17/845763

Inventors:

- Hawthorne NY, US
Partha P. Mitra - New York NY, US
Charles Cantor - Hawthorne NY, US
Eric Feinstein - Hawthorne NY, US

Assignee:

Clarapath, Inc. - Hawthorne NY

International Classification:

G01N 1/28
G01N 1/36
G01N 1/31
G01N 1/06
B01L 9/00

Abstract:

An integrated pathology system includes a tissue embedding module configured to embed a tissue sample into an embedding material to prepare a tissue block, a sectioning and slide creating module configured to remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides, a staining module configured to stain the one or more tissue sections on the slides, and a cover-slipper module configured to place a cover onto the one or more stained tissue sections. The system further includes one or more transfer devices configured to integrate the modules and a processor in communication with the modules for controlling one or more processes performed by the modules and the one or more transfer devices for controlling the integration of the modules.