Charles Qu Dong from 477 Springview Ln, Phoenixville, PA 19460, age 60

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Location:

Greater New York City Area

Industry:

Financial Services

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Location:

Greater New York City Area

Industry:

Accounting

Antibodies Against Inducible Th2 Cell Factors
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US Patent:

20080096981, Apr 24, 2008
Filed:

Dec 20, 2006
Appl. No.:

11/641774
Inventors:

Charles Dong - Dresher PA, US
Roy Levitt - Ambler PA, US
Nicholas Nicolaides - Boothwyn PA, US
Yuhong Zhou - Dresher PA, US
Jamila Louahed - Etterbeek, BE
W. Maloy - Lansdale PA, US
International Classification:

A61K 35/00
A61P 11/06
C07H 21/00
C07K 14/00
C07K 16/00
C07K 7/06
C12P 21/00
US Classification:

514789000, 435069100, 530329000, 530350000, 530387900, 536023500
Abstract:

A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.

Asthma Associated Factors As Targets For Treating Atopic Allergies Including Asthma And Related Disorders
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US Patent:

20090068185, Mar 12, 2009
Filed:

Mar 9, 2007
Appl. No.:

11/716051
Inventors:

Kenneth J. Holroyd - Plymouth Meeting PA, US
Roy C. Levitt - Plymouth Meeting PA, US
W. Lee Maloy - Plymouth Meeting PA, US
Jamila Louahed - Plymouth Meeting PA, US
Mike McLane - Plymouth Meeting PA, US
Nicholas C. Nicolaides - Plymouth Meeting PA, US
Yuhong Zhou - Plymouth Meeting PA, US
Charles Qu Dong - Dresher PA, US
International Classification:

A61K 39/395
C07H 21/00
A61K 31/56
A61P 11/06
A61K 31/7052
C07K 14/00
US Classification:

4241391, 536 231, 530350, 514169, 514 44
Abstract:

A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.