Charles E Mcintyre

US Patent:

6602872, Aug 5, 2003

Filed:

Nov 21, 2000

Appl. No.:

09/717277

Inventors:

Charles J. McIntyre - Lansdale PA
Nigel J. Liverton - Harleysville PA
David A. Claremon - Maple Glen PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D40304

US Classification:

51425202, 544238, 544122, 544 60, 540601, 540575, 51425203

Abstract:

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.

US Patent:

6870055, Mar 22, 2005

Filed:

Sep 17, 2001

Appl. No.:

10/362484

Inventors:

David A. Claremon - Maple Glen PA, US
Charles J. McIntyre - Lansdale PA, US
Nigel J. Liverton - Harleysville PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D217/22
C07D217/02
A61K031/47

US Classification:

546141, 546142, 514309, 514307

Abstract:

The present invention concerns certain isoquinolinone compounds and their utility as inhibitors of voltage-dependent potassium channels or currents, such as K1. 5 and I, that could serve as targets for the treatment of cardiac arrhythmias especially atrial arrhythmias. The present invention also provide a method for treating or preventing conditions which respond to the inhibition of potassium channels or currents, such as cardiac arrhythmias and more especially atrial arrhythmias. The present invention further includes pharmaceutical formulations and a process of making a pharmaceutical composition comprising a compound of certain isoquinolinone or its pharmaceutically acceptable salts, hydrates, solvates, crystal forms, and stereoisomers thereof, and a pharmaceutically acceptable carrier.

US Patent:

7259157, Aug 21, 2007

Filed:

Apr 2, 2002

Appl. No.:

10/114685

Inventors:

Nigel J. Liverton - Harleysville PA, US
John W. Butcher - Telford PA, US
Charles McIntyre - Lansdale PA, US
Christopher F. Claiborne - Cambridge MA, US
David A. Claremon - Maple Glen PA, US
John A. McCauley - Maple Glen PA, US
Joseph J. Romano - Berwyn PA, US
Wayne Thompson - Landsdale PA, US
Peter M. Munson - Harleysville PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/554
A61K 31/4965
A61K 31/44
A61K 31/425
A61K 31/52

US Classification:

51421101, 5142222, 5142288, 514250, 5142621, 51426322, 51425203, 51425505, 514256, 514314, 514315, 514330, 514336, 514351, 514354, 514357, 514365, 546169, 546180, 546193, 546194, 546198, 546199, 546201, 546207, 546208, 546209, 546210, 546211, 546212, 546213, 546224, 546226, 546229, 546231, 546236, 546237, 544238, 544262, 544277, 544335, 544406, 548146, 548189, 548200, 548202, 548203, 548204, 548205

Abstract:

Compounds represented by Formula (I):.

US Patent:

7452893, Nov 18, 2008

Filed:

Aug 11, 2004

Appl. No.:

10/568470

Inventors:

Wayne Thompson - Landsdale PA, US
Steven D. Young - Lansdale PA, US
Brian T. Phillips - Telford PA, US
Peter Munson - Harleysville PA, US
Willie Whitter - West Point PA, US
Nigel Liverton - Harleysville PA, US
Christine Dieckhaus - North Wales PA, US
John Butcher - Telford PA, US
John A. McCauley - Maple Glen PA, US
Charles J. McIntyre - Lansdale PA, US
Mark E. Layton - Harleysville PA, US
Philip E. Sanderson - Valley Forge PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 487/04
A61K 31/519

US Classification:

5142621, 544262

Abstract:

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson's disease, Alzheimer's disease, epilepsy, depression, anxiety, ischemic brain injury including stroke, and other conditions.

US Patent:

7470664, Dec 30, 2008

Filed:

Jul 12, 2006

Appl. No.:

11/484925

Inventors:

M. Katharine Holloway - Lansdale PA, US
Nigel J. Liverton - Harleysville PA, US
Steven W. Ludmerer - North Wales PA, US
John A. McCauley - Maple Glen PA, US
David B. Olsen - Lansdale PA, US
Michael T. Rudd - Collegeville PA, US
Joseph P. Vacca - Telford PA, US
Charles J. McIntyre - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 38/12
C07K 7/50

US Classification:

514 11, 514 9, 514 18, 514 19, 530331, 540455

Abstract:

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

US Patent:

7723352, May 25, 2010

Filed:

Sep 17, 2004

Appl. No.:

10/571870

Inventors:

B. Wesley Trotter - Glenside PA, US
Christopher Claiborne - Cambridge MA, US
Gerald S. Ponticello - Lansdale NJ, US
Charles J. McIntyre - Lansdale PA, US
Nigel Liverton - Harleysville PA, US
David A. Claremon - Maple Glen PA, US

Assignee:

Merck Sharp & Dohme - Rahway NJ

International Classification:

C07D 471/02
A61K 31/47

US Classification:

514292, 546 94

Abstract:

The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

US Patent:

7741322, Jun 22, 2010

Filed:

Sep 17, 2004

Appl. No.:

10/571858

Inventors:

Christopher J. Dinsmore - Schwenksville PA, US
Jeffrey M. Bergman - Sellersville PA, US
Charles J. McIntyre - Lansdale PA, US
Richard Isaacs - Harleysville PA, US
David A. Claremon - Maple Glen PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/4725
C07D 401/12

US Classification:

5142352, 514309, 544128, 546141

Abstract:

The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

US Patent:

7763614, Jul 27, 2010

Filed:

Sep 22, 2004

Appl. No.:

10/572236

Inventors:

Richard Isaacs - Harleysville PA, US
Christopher J. Dinsmore - Newton MA, US
B. Wesley Trotter - Glenside NJ, US
Nigel Liverton - Harleysville PA, US
Douglas C. Beshore - Harleysville PA, US
Nathan R. Kett - Perkiomenville PA, US
Charles J. McIntyre - Lansdale PA, US
Kausik K. Nanda - Norristown PA, US
David A. Claremon - Maple Glen PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 401/02
A61K 31/47

US Classification:

5142352, 51425305, 514256, 514309, 544128, 544242, 544363, 546141

Abstract:

The present invention relates to compounds of structural formula I: I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.