Bing Guan - Chestnut Hill MA, US Charles Minor - Kingston MA, US Mingshi Dai - Billerica MA, US Shomir Ghosh - Brookline MA, US Tracy J. Jenkins - Belmont MA, US Gang Li - Framingham MA, US Douglas F. Burdi - Arlington MA, US Robert A. Bennett - Milford MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 211/06 C07D 211/68
US Classification:
546195, 546192
Abstract:
Disclosed are CCR8 inhibitors represented by Structural Formulas (I):The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.
Aryl Sulfonamides Useful As Inhibitors Of Chemokine Receptor Activity
Mingshi Dai - Billerica MA, US Bing Guan - Needham MA, US Robert A. Bennett - Milford MA, US Douglas F. Burdi - Arlington MA, US Shomir Ghosh - Brookline MA, US Gang Li - Westborough MA, US Charles Minor - Kingston MA, US Tracy J. Jenkins - Belmont MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 211/06 C07D 215/38 C07D 413/00 C07D 239/02
US Classification:
546206, 546158, 546169, 544129, 544298
Abstract:
The present invention provides compounds of general formula I:.
Aryl Sulfonamides Useful As Inhibitors Of Chemokine Receptor Activity
Mingshi Dai - Lexington MA, US Bing Guan - Needham MA, US Robert A. Bennett - Milford MA, US Douglas F. Burdi - Arlington MA, US Shomir Ghosh - Brookline MA, US Gang Li - Westborough MA, US Charles A. Minor - Kingston MA, US Tracy J. Jenkins - Belmont MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 215/38
US Classification:
546159, 546163, 514312
Abstract:
The present invention provides compounds of general formula I:or a pharmaceutically acceptable salt thereof, wherein R, X, Z, R, X, Ar, n, Rand Rare defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
Mingshi Dai - Billerica MA, US Tracy Jenkins - Belmont MA, US Bing Guan - Chestnut Hill MA, US Shomir Ghosh - Brookline MA, US Charles Minor - Kingston MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K031/47 C07D217/06 C07D217/12
US Classification:
514/310000, 514/311000, 546/146000, 546/176000
Abstract:
Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
Name / Title
Company / Classification
Phones & Addresses
Charles Minor President
Liberia Embassy International Affairs
5201 16Th St Nw, Washington, DC 20011 Website: embassyofliberia.org
Charles Minor President
Liberia Embassy International Affairs
5201 16 St NW, Washington, DC 20011 (202)7230437, (202)7230436
Charles Minor Branch Manager, Manager
Government of Liberia, Ministry of National Embassy · Executive Office · International Affairs
5201 16 St NW, Washington, DC 20011 (202)7230437
Charles D. Minor Incorporator
SCIOTO METALS, INC
Charles Minor President, Principal
G. ELMER JOHNSON MEMORIAL AND EDUCATIONAL FOUNDATION INC Civic/Social Association
640 Harvard St, Mattapan, MA 02126 Same As Above Ma 00000 Usa<Br/>7 Bailey Cir, Kingston, MA 02364