Chen Fen Zhu

US Patent:

20050119502, Jun 2, 2005

Filed:

Nov 13, 2002

Appl. No.:

10/495797

Inventors:

David Gschneidner - Tarrytown NY, US
Kelly Kraft - Tarrytown NY, US
Chen Zhu - Berkeley Heights NJ, US
Yi Chen - Hamden CT, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K038/28
A61K038/16
A61K031/727
A61K038/18
A61K038/22

US Classification:

562439000, 562442000, 564047000, 564284000, 564285000, 564346000, 514012000, 514008000, 514003000, 514056000, 424085400, 514457000

Abstract:

Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

20190074908, Mar 7, 2019

Filed:

Sep 6, 2017

Appl. No.:

15/696939

Inventors:

- Espoo, FI
Vincent Houtsma - New Providence NJ, US
Doutje van Veen - New Providence NJ, US
Chen Zhu - Edison NJ, US
Noriaki Kaneda - Westfield NJ, US
Michael Eggleston - New York NY, US

Assignee:

Nokia Solutions and Networks OY - Espoo

International Classification:

H04B 10/61
G06F 11/14

Abstract:

A coherent optical receiver having an analog electrical circuit connected to combine the outputs of multiple photodetectors to generate an electrical output signal from which the data encoded in a received modulated optical signal can be recovered in a robust and straightforward manner. In an example embodiment, the analog electrical circuit includes one or more transimpedance amplifiers connected between the photodetectors and the receiver's output port. The coherent optical receiver may include a dual-polarization optical hybrid coupled to eight photodiodes to enable polarization-insensitive detection of the received modulated optical signal. The signal processing implemented in the analog electrical circuit advantageously enables the use of relatively inexpensive local-oscillator sources that may have relaxed specifications with respect to linewidth and wavelength stability. Different embodiments of the analog electrical circuit can be used to enable the receiver to receive amplitude- and intensity-encoded modulated optical signals.

US Patent:

20140348842, Nov 27, 2014

Filed:

Apr 29, 2014

Appl. No.:

14/264791

Inventors:

- Boston MA, US
Eugene K. Cha - Muttontown NY, US
Sumone Chakravarti - Victoria, AU
Catherine Sabatos - San Francisco CA, US
Chen Zhu - Brookline MA, US
Xin Xiao Zheng - Wellesley MA, US
Alberto Sanchez-Fueyo - Barcelona, ES

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA
Beth Israel Deaconess Medical Center, Inc. - Boston MA

International Classification:

C07K 16/18

US Classification:

4241391

Abstract:

The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.