Cheng C Chen

US Patent:

20020107391, Aug 8, 2002

Filed:

Oct 18, 2001

Appl. No.:

09/982483

Inventors:

Lisa Frey - Somerset NJ, US
Cheng Chen - Plainsboro NJ, US
Jing Li - Edison NJ, US
Zhiguo Song - Edison NJ, US
Lushi Tan - Edison NJ, US
Richard Tillyer - Cranford NJ, US
David Tschaen - Holmdel NJ, US
Matthew Zhao - Edison NJ, US

International Classification:

C07D279/08
C07D265/36
C07D498/02

US Classification:

544/047000, 544/105000, 544/253000, 544/235000, 544/349000, 546/112000, 548/152000, 548/217000, 548/302700, 548/360100, 548/452000

Abstract:

The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below:

US Patent:

20090247770, Oct 1, 2009

Filed:

Aug 3, 2007

Appl. No.:

12/309999

Inventors:

Kevin R. Campos - Berkeley Heights NJ, US
Cheng Chen - Plainsboro NJ, US
Hideaki Ishibashi - Ibaraki, JP
Shinji Kato - Ibaraki, JP
Artis Klapars - Edison NJ, US
Yoshinori Kohmura - Ibaraki, JP
David J. Pollard - Monroe NJ, US
Akihiro Takezawa - Ibaraki, JP
Jacob H. Waldman - Westfield NJ, US
Debra Wallace - Herts, GB
Nobuyoshi Yasuda - Mountainside NJ, US

International Classification:

C07D 207/24

US Classification:

548550

Abstract:

The present invention is directed to a process for preparing α,α disubstituted γ-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

US Patent:

62813919, Aug 28, 2001

Filed:

Oct 27, 1999

Appl. No.:

9/427413

Inventors:

Richard D. Tillyer - Westfield NJ
Ian W. Davies - Princeton NJ
Robert D. Larsen - Bridgewater NJ
Xin Wang - Kirkland, CA
Paul O'Shea - Montreal, CA
Anthony On-Ping King - Hillsborough NJ
Dalian Zhao - Fanwood NJ
Cheng Y. Chen - Colonia NJ
Edward J. J. Grabowski - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ
Merck Frosst Canada & Co. - Kirkland

International Classification:

C07C31920

US Classification:

568 43

Abstract:

This invention encompasses a novel process for synthesizing compounds represented by formula A: ##STR1## These compounds are intermediates useful in the preparation of certain agents that are selective COX-2 inhibitors.

US Patent:

60058463, Dec 21, 1999

Filed:

May 7, 1997

Appl. No.:

8/852656

Inventors:

Reginald P. Best - Somerset NJ
Daniel M. Brennan - Hillsdale NJ
Cheng T. Chen - Holmdel NJ

Assignee:

3Com Corporation - Santa Clara CA

International Classification:

H04L 1216
H04J 312

US Classification:

370264

Abstract:

Apparatus for an improved ISDN terminal adapter (5) and accompanying methods for use therein. The adapter provides automatic ISDN switch detection, automatic SPID configuration, baud rate unblocking and automatic data compression. Specifically, the adapter automatically detects a type of ISDN switch (480) to which the adapter is connected by analyzing D-channel initialization messages which are received by the adapter from the switch as well as specific responses to ISDN messages sent by the adapter. The switch type value is then used, during SPID determination, in conjunction with a telephone area code of the user, to access an internal database (435) of predefined SPID formats, referenced in terms of particular telephone service areas and switch types, to access the possible SPID format(s) for the ISDN switch. Firmware (460) executing within the adapter, in conjunction with software executing within the DTE, forms one of more SPID(s) appropriate for the switch, queries the switch with each of these SPIDs to select and verify a correct SPID from those formed, and, if necessary, further refine and update the switch type previously determined.

US Patent:

59319283, Aug 3, 1999

Filed:

May 7, 1997

Appl. No.:

8/852657

Inventors:

Daniel M. Brennan - Hillsdale NJ
Cheng T. Chen - Holmdel NJ

Assignee:

3Com Corporaton - Santa Clara CA

International Classification:

G06F 1314
G06F 1320

US Classification:

710 68

Abstract:

Apparatus for an improved ISDN terminal adapter (5) and accompanying methods for use therein. The adapter provides automatic ISDN switch detection, automatic SPID configuration, baud rate unblocking and automatic data compression. Specifically, the adapter automatically provides B-channel data compression in the event the DTE is unwilling or unable to do so. Here, the adapter monitors negotiation, over an ISDN line, of a compression control protocol (CCP) between the DTE and its PPP peer (380). If the negotiations reveal that the DTE will not undertake compression, then the adapter will then automatically negotiate the protocol and thereafter, for the duration of a call, perform compression and decompression in lieu of the DTE.

US Patent:

6015926, Jan 18, 2000

Filed:

May 11, 1998

Appl. No.:

9/075476

Inventors:

Cheng Yi Chen - Colonia NJ
Lushi Tan - Edison NJ
Richard D. Tillyer - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07C21145
C07D26518

US Classification:

564442

Abstract:

An efficient method for the preparation of key intermediate, in the synthesis of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one, a reverse transcriptase inhibitor is achieved using a chiral addition reaction to the 4-chloro-2-trifluoromethylketoaniline with an organozinc complex to give the desired alcohol. This instant method has broad applicability in the chiral addition to any prochiral ketone.

US Patent:

58564926, Jan 5, 1999

Filed:

Jan 5, 1998

Appl. No.:

/002853

Inventors:

Cheng Yi Chen - Colonia NJ
Feng Xu - Staten Island NY
Richard D. Tillyer - Westfield NJ
Dalian Zhao - Fanwood NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D21120
C07D20712

US Classification:

546185

Abstract:

An efficient method for the quantitative preparation and isolation of a compound of formula I ##STR1## or its enantiomer, a chiral mediator used in enantioselective synthesis.

US Patent:

61405159, Oct 31, 2000

Filed:

Sep 15, 1998

Appl. No.:

9/153403

Inventors:

Cheng Y. Chen - Colonia NJ
Lushi Tan - Edison NJ
Robert D. Larsen - Bridgewater NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D30712
C07D30726
C07D40112
C07D40512
C07C31500

US Classification:

549324

Abstract:

Described is a process of preparing 3-aryl, 4-aryloxy furan-5-ones which are useful as inhibitors of cyclooxygenase-2 (COX-2). Such compounds are useful as anti-inflammatory agents. The process is directed to an asymmetric synthesis which involves: a trisubstituted styrene derivative preparation via Horner-Wadsworth-Emmons reaction and subsequent one pot trifluoromethylation of the allylic alcohol; preparation of the. alpha. -hydroxyl ketone using Sharpless asymmetric dihydroxylation and Swern oxidation; the esterification of the. alpha. -hydroxyl ketone with the phenoxy acetic acid; and the Dieckman condensation of the resulting ester.