Cheng F Chen

US Patent:

6495713, Dec 17, 2002

Filed:

Jan 17, 2002

Appl. No.:

10/052088

Inventors:

Cheng Yi Chen - Plainsboro NJ
Weirong Chen - Iselin NJ
Paul OShea - Westmount, CA
Lushi Tan - Edison NJ
Richard Tillyer - Cranford NJ
Feng Xu - Staten Island NY
Philippe Dagneau - Verdun, CA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07C 6966

US Classification:

560179, 560187, 560188, 560198, 560201, 568 31, 568 32

Abstract:

This invention encompasses a process for making a compound of Formula A These compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammnatory agents.

US Patent:

7183425, Feb 27, 2007

Filed:

Jul 29, 2005

Appl. No.:

11/193798

Inventors:

Cheng Yi Chen - Plainsboro NJ, US
Paul N. Devine - Tinton Falls NJ, US
Bruce S. Foster - Scotch Plains NJ, US
Greg Hughes - Beaconsfield, CA
Paul O'Shea - Westmount, CA

Assignee:

Merck Frosst Canada Ltd. - Quebec

International Classification:

C07C 229/00

US Classification:

560 40

Abstract:

This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.

US Patent:

20020107391, Aug 8, 2002

Filed:

Oct 18, 2001

Appl. No.:

09/982483

Inventors:

Lisa Frey - Somerset NJ, US
Cheng Chen - Plainsboro NJ, US
Jing Li - Edison NJ, US
Zhiguo Song - Edison NJ, US
Lushi Tan - Edison NJ, US
Richard Tillyer - Cranford NJ, US
David Tschaen - Holmdel NJ, US
Matthew Zhao - Edison NJ, US

International Classification:

C07D279/08
C07D265/36
C07D498/02

US Classification:

544/047000, 544/105000, 544/253000, 544/235000, 544/349000, 546/112000, 548/152000, 548/217000, 548/302700, 548/360100, 548/452000

Abstract:

The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below:

US Patent:

20090247770, Oct 1, 2009

Filed:

Aug 3, 2007

Appl. No.:

12/309999

Inventors:

Kevin R. Campos - Berkeley Heights NJ, US
Cheng Chen - Plainsboro NJ, US
Hideaki Ishibashi - Ibaraki, JP
Shinji Kato - Ibaraki, JP
Artis Klapars - Edison NJ, US
Yoshinori Kohmura - Ibaraki, JP
David J. Pollard - Monroe NJ, US
Akihiro Takezawa - Ibaraki, JP
Jacob H. Waldman - Westfield NJ, US
Debra Wallace - Herts, GB
Nobuyoshi Yasuda - Mountainside NJ, US

International Classification:

C07D 207/24

US Classification:

548550

Abstract:

The present invention is directed to a process for preparing α,α disubstituted γ-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

US Patent:

20130274463, Oct 17, 2013

Filed:

Dec 13, 2011

Appl. No.:

13/993541

Inventors:

Cheng Chen - Plainsboro NJ, US
Guy Humphrey - Hillsborough NJ, US
Sarah Dolman - Jersey City NJ, US
Hongmei Li - Edison NJ, US
Matthew T. Tudge - Chatman NJ, US
Kelvin Yong - Lyndhurst NJ, US
Bangping Xiang - Plainsboro NJ, US
Michael Zacuto - Jersey City NJ, US

International Classification:

C07D 498/16
C07D 209/44
C07C 271/56
C07C 309/85
C07C 311/47
C07D 403/12
C07C 309/80

US Classification:

540456, 548482, 568 35, 568 28, 560115

Abstract:

The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.

US Patent:

62813919, Aug 28, 2001

Filed:

Oct 27, 1999

Appl. No.:

9/427413

Inventors:

Richard D. Tillyer - Westfield NJ
Ian W. Davies - Princeton NJ
Robert D. Larsen - Bridgewater NJ
Xin Wang - Kirkland, CA
Paul O'Shea - Montreal, CA
Anthony On-Ping King - Hillsborough NJ
Dalian Zhao - Fanwood NJ
Cheng Y. Chen - Colonia NJ
Edward J. J. Grabowski - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ
Merck Frosst Canada & Co. - Kirkland

International Classification:

C07C31920

US Classification:

568 43

Abstract:

This invention encompasses a novel process for synthesizing compounds represented by formula A: ##STR1## These compounds are intermediates useful in the preparation of certain agents that are selective COX-2 inhibitors.

US Patent:

60058463, Dec 21, 1999

Filed:

May 7, 1997

Appl. No.:

8/852656

Inventors:

Reginald P. Best - Somerset NJ
Daniel M. Brennan - Hillsdale NJ
Cheng T. Chen - Holmdel NJ

Assignee:

3Com Corporation - Santa Clara CA

International Classification:

H04L 1216
H04J 312

US Classification:

370264

Abstract:

Apparatus for an improved ISDN terminal adapter (5) and accompanying methods for use therein. The adapter provides automatic ISDN switch detection, automatic SPID configuration, baud rate unblocking and automatic data compression. Specifically, the adapter automatically detects a type of ISDN switch (480) to which the adapter is connected by analyzing D-channel initialization messages which are received by the adapter from the switch as well as specific responses to ISDN messages sent by the adapter. The switch type value is then used, during SPID determination, in conjunction with a telephone area code of the user, to access an internal database (435) of predefined SPID formats, referenced in terms of particular telephone service areas and switch types, to access the possible SPID format(s) for the ISDN switch. Firmware (460) executing within the adapter, in conjunction with software executing within the DTE, forms one of more SPID(s) appropriate for the switch, queries the switch with each of these SPIDs to select and verify a correct SPID from those formed, and, if necessary, further refine and update the switch type previously determined.

US Patent:

59319283, Aug 3, 1999

Filed:

May 7, 1997

Appl. No.:

8/852657

Inventors:

Daniel M. Brennan - Hillsdale NJ
Cheng T. Chen - Holmdel NJ

Assignee:

3Com Corporaton - Santa Clara CA

International Classification:

G06F 1314
G06F 1320

US Classification:

710 68

Abstract:

Apparatus for an improved ISDN terminal adapter (5) and accompanying methods for use therein. The adapter provides automatic ISDN switch detection, automatic SPID configuration, baud rate unblocking and automatic data compression. Specifically, the adapter automatically provides B-channel data compression in the event the DTE is unwilling or unable to do so. Here, the adapter monitors negotiation, over an ISDN line, of a compression control protocol (CCP) between the DTE and its PPP peer (380). If the negotiations reveal that the DTE will not undertake compression, then the adapter will then automatically negotiate the protocol and thereafter, for the duration of a call, perform compression and decompression in lieu of the DTE.