Paul L. Hallenbeck - Chester Springs PA, US Laura M. Hales - Chester Springs PA, US Carl M. Hay - Damascus MD, US Shanthi Ganesh - San Francisco CA, US Ling Xu - Boyds MD, US Jingping Yang - Gaithersburg MD, US Cheng Cheng - Rockville MD, US
Assignee:
Norvartis AG - Basel
International Classification:
C12N 7/00 A61K 35/00 C12N 15/63
US Classification:
4352351, 424 931, 4353201
Abstract:
The present invention relates to a novel RNA that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
Seneca Valley Virus Based Compositions And Methods For Treating Disease
Paul Hallenbeck - Chester Springs PA, US Seshidhar Reddy Police - Chester Springs PA, US Laura M. Hales - Chester Springs PA, US Carl Hay - Damascus MD, US Shanthi Ganesh - San Francisco CA, US Ling Xu - Boyds MD, US Jingping Yang - Gaithersburg MD, US Cheng Cheng - Rockville MD, US
Assignee:
Novartis AG - Basel
International Classification:
C12N 15/11 A61K 35/00
US Classification:
536 2372, 4352351, 424 931
Abstract:
The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
Cheng Cheng - Rockville MD, US Lori Clarke - Olney MD, US Sheila Connelly - Ijamsville MD, US David Ennist - Bethesda MD, US Mario Gorziglia - Doylestown PA, US Paul Hallenbeck - Gaithersburg MD, US Carl Hay - Damascus MD, US John Jakubczak - Germantown MD, US Michael Kaleko - Rockville MD, US Sandrina Phipps - Reston VA, US Seshidhar Police - Gaithersburg MD, US Patricia Ryan - Montgomery Village MD, US David Stewart - Eldersburg MD, US Yuefeng Xie - Germantown MD, US
International Classification:
C12N015/861 C12N009/22 C12N007/00
US Classification:
435/456000, 435/199000, 435/235100, 435/320100
Abstract:
The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
Martin Woodle - Bethesda MD, US Cheng Cheng - Rockville MD, US Kas Subramanian - Edison NJ, US Richard Titmas - Boxford MA, US Jingping Yang - N. Potomac MD, US Joerg Frei - Helstein, CH Helmut Mett - Neuenburg, DE Jaroslav Stanek - Arlesheim, CH
International Classification:
A61K048/00 C12N015/00
US Classification:
514/044000, 435/320100
Abstract:
Non-naturally occurring vector for gene therapy are provided, comprised of chemically defined reagents, where the vector is self-assembling and where the vector comprises (1) a core complex comprising a nucleic acid and (2) at least one complex forming reagent, where the vector has fusogenic activity. The vector optionally may contain reagents permitting fusion with cell membranes and nuclear uptake. The vector also may contain an outer shell moiety that is anchored to the core complex, whereby the outer shell stabilizes the complex, protects it from unwanted interactions and enhances delivery of the nucleic acid into a target tissue or cell. The outer shell optionally may be sheddable, that is, it may be designed such that it dissociates from the vector upon entry into the target cell or tissue.
Jason Gall - Germantown MD, US Thomas Wickham - Billerica MA, US William Enright - North Potomac MD, US Douglas Brough - Gaithersburg MD, US Mohammed Zuber - Fredrick MD, US C. King - Washington DC, US Gary Nabel - Bethesda MD, US Cheng Cheng - Bethesda MD, US
International Classification:
A61K 39/12 A61K 39/395
US Classification:
424199100, 424204100, 424130100
Abstract:
The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80% or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.
Method Of Using Adenoviral Vectors To Induce An Immune Response
Gary Nabel - Washington DC, US Cheng Cheng - Bethesda MD, US Wing-Pui Kong - Gaitersburg MD, US Jason Gall - Germantown MD, US C. Richter King - Washington DC, US
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
A61K 39/12 C12N 15/861
US Classification:
424199100, 424093200, 435456000
Abstract:
The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
Adenovirus Fiber Shaft Composition And Methods Of Use
The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.
Method Of Using Adenoviral Vectors With Increased Immunogenicity In Vivo
Gary Nabel - Washington DC, US Cheng Cheng - Bethesda MD, US Jason Gall - Germantown MD, US Thomas Wickham - Groton MA, US
Assignee:
The Government of the U.S.A., as represented by the Secretary, Department of Health and Human Ser - Rockville MD and Human Services - Rockville MD GenVec, Inc. - Gaitherburg MD GenVec, Inc. - Gaithersburg MD
International Classification:
A61K 39/00 A61P 37/04 C12N 15/63
US Classification:
424199100, 435320100
Abstract:
The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.
Resumes
Phd Student In Sociology And Demography At Princeton University
Princeton University since Aug 2012
PhD Student
Applied Population Laboratory, University of Wisconsin-Madison - Madison, Wisconsin Area Sep 2009 - May 2012
CAR Intern
Wisconsin Scholars Longitudinal Study - Madison, Wisconsin Area Jun 2009 - May 2012
CAR Intern
Centre for Economic and Social Studies, Hyderabad, India - Hyderabad Area, India Jun 2011 - Jul 2011
Junior Research Assistant
University of Wisconsin-Madison - Madison, Wisconsin Area Jan 2010 - May 2010
Undergraduate Research Scholar
Education:
Princeton University 2012 - 2017
Doctor of Philosophy (Ph.D.), Sociology
University of Wisconsin-Madison 2008 - 2012
Bachelor of Arts (B.A.), Sociology, Concentration in Analysis and Research, Comprehensive Honors
Skills:
Statistics Stata R Excel Quantitative Analysis Matlab SAS/SQL ArcGIS NVivo Epidata Emacs Linux LaTeX SPSS Research Data Analysis Microsoft Office PowerPoint Data Management Database Management
Languages:
English Chinese German
Awards:
2011-2012 Wisconsin Hilldale Undergraduate/Faculty Research Fellowship University of Wisconsin-Madison The Hilldale Undergraduate/Faculty Research Fellowship supports my senior thesis on the health effects of retirement and children. E. Walter Terrie Applied Demography Paper Award 2010 Southern Demographic Association Winkler, Richelle, Shaun Golding and Cheng Cheng. 2010. “Boom and bust? Population Dynamics in Natural Resource Dependent Counties.” Dean's List College of Letters and Science, University of Wisconsin-Madison Honorable Mention, International Undergraduate Writing Contest of 2009 Department of English, University of Wisconsin- Madison “Chinese Higher Education: Adopting and Learning” Phi Beta Kappa College of Letters and Science, University of Wisconsin-Madison Alfred Reschke Undergraduate Scholarship Department of Sociology, University of Wisconsin-Madison The Sociology Department awards the Alfred Reschke Scholarships to four students every year for support during their senior years. The awards are, by and large, merit based.
NIH since Jun 2003
Manager
GTI Novartis 1997 - 2003
Lab head
Genetic Therapy, Inc. 1997 - 2003
lab head
Inex Pharmaceuticals 1995 - 1997
Scientist
University of Washington 1991 - 1995
Senior fellow
Education:
Nagoya University 1988 - 1991
PhD, Microbiology
Ibaraki University 1986 - 1988
MS, Applied Microbiology
Research Assistant at Purdue University, Intern - MTS- Cloud Management Platform at VMware
Location:
West Lafayette, Indiana
Industry:
Computer Software
Work:
Purdue University - West Lafayette, IN since Aug 2012
Research Assistant
VMware since May 2012
Intern - MTS- Cloud Management Platform
Purdue University May 2011 - May 2012
Teaching Assistant
MOE-Microsoft Key Laboratory of Statistics and Information Technology of Peking University Jan 2010 - May 2010
Research Assistant
Education:
Purdue University 2010 - 2015
Doctor of Philosophy (Ph.D.), Computer Science
Purdue University 2010 - 2012
Master of Science (M.S.), Computer Science
Beijing institute of Technology, Zhuhai 2005 - 2009
Bachelor of Engineering (B.Eng.), Computer Software Engineering
Skills:
C C++ C# Java Python R Shell Scripting Bash tcl HTML x86 Assembly MIPS Assembly Vim Emacs Eclipse Visual Studio UML Git Tortoise SVN OpenMP MPI Microsoft Office vSphere VirtualBox XenServer
The development of such chips allows researchers to test the effect of drugs now in development and to ask and test fundamental biological questions, said associate professor Amar Basu and Mark Ming-Cheng Cheng, associate professor of WSU Electrical and Computer Engineering.
Date: Jun 19, 2015
Source: Google
China Panda Virus Kills Two Pandas, Leaves Third In Important Condition
Da Bao, an eight-year-old panda, died from heart failure and lung edema from the virus on Jan. 4. Yet another eight-year-old panda Cheng Cheng died on Dec. 9, according toXinhua. Panda breeding centers in the neighboring Sichuan province have instituted emergency measures, like enhanced disinfecti
Canine distemper virus, which can kill 80 percent of pandas infected with the microorganism, recently took the lives of Dabao and Cheng cheng. Dabao passed away on January 4, 2015, more than a month after the death of Cheng Cheng, who succumbed to the disease on December 9, 2014.
Date: Jan 17, 2015
Category: Health
Source: Google
Another Giant Panda in Critical Condition due to Canine distemper virus
As mentioned above, on January 4, Da Bao, an eight-year-old panda, died from heart failure and lung edema from the virus. Second death involved an eight-year-old panda Cheng Cheng and it died on December 9.
Date: Jan 17, 2015
Category: Health
Source: Google
China Panda Virus Kills Two Pandas, Leaves Third In Critical Condition
Da Bao, an 8-year-old panda, died from heart failure and lung edema from the virus on Jan. 4. Another 8-year-old panda Cheng Cheng died on Dec. 9, according toXinhua. Panda breeding centers in the neighboring Sichuan province have instituted emergency measures, including enhanced disinfection of p
environmental changes that cause extinction. In a Genome Biology study led by Shengbin Li, Cheng Cheng and Jun Yu from Xi'an Jiaotong University and Jarvis, researchers analyzed the genomes of species that have recently gone nearly extinct, including the crested ibis in Asia and the bald eagle in the Americas.
extinction. In a Genome Biology study led by Shengbin Li, Cheng Cheng and Jun Yu from Xi'an Jiaotong University, Huanming Yang from BGI and Jarvis, researchers analyzed the genomes of species that have recently gone nearly extinct, including the crested ibis in Asia and the bald eagle in the Americas.
Date: Dec 12, 2014
Category: Sci/Tech
Source: Google
PBOC move lowers Taiwan's chance of hiking interest rates
Cheng Cheng-Mount, president of the Taiwan Academy of Banking and Finance, said that Taiwan is a relatively small economy, which is sensitive to any policy adjustment made by its neighboring countries, including China.
Date: Nov 21, 2014
Source: Google
Googleplus
Cheng Cheng
Education:
University of Oxford - Materials
Tagline:
Play with small stuff (nano size) and turn them into electricity to save the world.
Cheng Cheng
Education:
University of Southern California - Electrical Engineering, VLSI
Cheng Cheng
Education:
University of Edinburgh - Digital Media
Cheng Cheng
Cheng Cheng
Education:
University of Glasgow
Cheng Cheng
Education:
Columbia University - Computer science
Cheng Cheng
Cheng Cheng
Youtube
Macaframa Phill Cheng
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joe cheng
second video by me..joe cheng..this song is say you will love me
Category:
Music
Uploaded:
24 Sep, 2006
Duration:
4m 27s
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