Cheng Xun Lu

US Patent:

6544503, Apr 8, 2003

Filed:

May 1, 2000

Appl. No.:

09/563037

Inventors:

John W. Vanderhoff - Bethlehem PA
Cheng Xun Lu - Somerset NJ
Clarence C. Lee - Lilburn GA
Chi-Chun Tsai - Lawrenceville GA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ
Lehigh University - Bethlehem PA

International Classification:

A61K 3174

US Classification:

424 7817, 424489, 424423, 424422

Abstract:

The invention is a process for the preparation of crosslinked water-swellable polymer particles. First, an aqueous polymer solution containing a water-soluble polymer having at least one functional group or charge, is combined with aqueous medium. The aqueous polymer solution is then mixed under moderate agitation with an oil medium and an emulsifier to form an emulsion of droplets of the water-soluble polymer. A crosslinking agent capable of crosslinking the functional groups and/or charges in the water-soluble polymer is then added to the emulsion to form crosslinked water-swellable polymer particles. The invention also includes the particles formed by the process and aqueous dispersions containing the particles which are useful for administering to an individual. The particles of the invention are useful for implantation, soft tissue augmentation, and scaffolding to promote cell growth.

US Patent:

6969531, Nov 29, 2005

Filed:

Aug 26, 2003

Appl. No.:

10/649082

Inventors:

Philip Dehazya - Westbury NY, US
Cheng Lu - Livingston NJ, US

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

C08B037/00
A61K009/50

US Classification:

424493, 536 54, 536115, 536118, 536124, 514 54, 424489

Abstract:

The present invention relates to microspheres comprising hyaluronan derivatized with a bifunctional crosslinker to form microspheres. Methods of making such microspheres, comprising mixing hyaluronic acid and a dihydrazide with a crosslinker in an aqueous solution, adding a solvent and an emulsifying agent to form an emulsion, and lowering the pH of the emulsion to allow intramolecular and intermolecular crosslinking to occur, are also disclosed. The invention also provides for pharmaceutical or cosmetic formulations based on the microspheres described herein, further containing one or more active or cosmetic agents, and methods of using such formulations.

US Patent:

20030096734, May 22, 2003

Filed:

Dec 5, 2002

Appl. No.:

10/310629

Inventors:

Philip Dehazya - Westbury NY, US
Cheng Lu - Livingston NJ, US

Assignee:

Clear Solutions Biotech, Inc.

International Classification:

A61K031/00
C08B037/00
A61K031/728

US Classification:

514/001000, 514/054000, 536/053000

Abstract:

The present invention relates to microspheres comprising hyaluronan derivatized with a bifunctional crosslinker to form microspheres. Methods of making such microspheres, comprising mixing hyaluronic acid and a dihydrazide with a crosslinker in an aqueous solution, adding a solvent and an emulsifying agent to form an emulsion, and lowering the pH of the emulsion to allow intramolecular and intermolecular crosslinking to occur, are also disclosed. The invention also provides for pharmaceutical or cosmetic formulations based on the microspheres described herein, further containing one or more active or cosmetic agents, and methods of using such formulations.

US Patent:

6214331, Apr 10, 2001

Filed:

Dec 12, 1997

Appl. No.:

8/989888

Inventors:

John W. Vanderhoff - Bethlehem PA
Cheng Xun Lu - Somerset NJ
Clarence C. Lee - Lilburn GA
Chi-Chun Tsai - Lawrenceville GA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ
Lehigh University - Bethlehem PA

International Classification:

A61K 910
A61K 4736
A61L 2752

US Classification:

424 7817

Abstract:

The invention is a process for the preparation of crosslinked water-swellable polymer particles. First, an aqueous polymer solution containing a water-soluble polymer having at least one functional group or charge, is combined with aqueous medium. The aqueous polymer solution is then mixed under moderate agitation with an oil medium and an emulsifier to form an emulsion of droplets of the water-soluble polymer. A crosslinking agent capable of crosslinking the functional groups and/or charges in the water-soluble polymer is then added to the emulsion to form crosslinked water-swellable polymer particles. The invention also includes the particles formed by the process and aqueous dispersions containing the particles which are useful for administering to an individual. The particles of the invention are useful for implantation, soft tissue augmentation, and scaffolding to promote cell growth.