Sun Cheng () (died 132) was an eunuch during Han Dynasty who, contrary to the stereotypes of Han eunuchs being corrupt and power-hungry, was loyal to the
State University of New York at Binghamton 2009 - 2013
Master of Arts (MA), Anthropology
State University of New York at Binghamton 2009 - 2013
Master of Science (MS), Biomedical Anthropology
Xiang Zhang - Alamo CA, US Jonathan A. Ellman - Oakland CA, US Fanqing Frank Chen - Moraga CA, US Cheng Sun - Evanston IL, US Kai-Hang Su - Seoul, KR
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01J 3/44
US Classification:
356301
Abstract:
A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.
Optical Platform For Simultaneously Stimulating, Manipulating, And Probing Multiple Living Cells In Complex Biological Systems
Sheng Wang - Albany CA, US Cheng Sun - Wilmette IL, US Xiang Zhang - Alamo CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
G06F 19/00 G01N 21/00
US Classification:
702 19
Abstract:
An optical platform and system for the simultaneous stimulation, manipulation and probing of multiple living cells in complex biological systems. The apparatus utilizes a spatiotemporal light modulator to expose a sample to pinpoints of light at selected times and wavelengths in two or three dimensional space and then detect the responses. In one embodiment, a spatiotemporal light modulator is optically coupled to a variable wavelength light source, a lens system and a system control unit with sample response sensors, wherein sample responses are detected after exposure to patterns of light in real time. Light patterns can be modulated in response to sample responses.