Cheng Yu

US Patent:

7586008, Sep 8, 2009

Filed:

Jul 9, 2008

Appl. No.:

12/170314

Inventors:

Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Neil P. Desai - Los Angeles CA, US
Vuong Trieu - Calabasas CA, US

Assignee:

Abraxis Bioscience, Inc. - Los Angeles CA

International Classification:

C07C 49/00
C07C 325/00
C07F 9/02
A61K 31/12
A61K 31/125

US Classification:

568325, 568 20, 568 25, 568333, 568336, 558177, 514438, 514675, 514687, 514690

Abstract:

The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.

US Patent:

7700612, Apr 20, 2010

Filed:

Dec 23, 2004

Appl. No.:

10/583803

Inventors:

Patrick Soon-Shiong - Los Angeles CA, US
Neil P. Desai - Santa Monica CA, US
Chunlin Tao - Beverly Hills CA, US
Cheng Zhi Yu - San Diego CA, US

Assignee:

Abraxis BioScience, LLC - Los Angeles CA

International Classification:

A61K 31/4745
C07D 491/22

US Classification:

514283, 546 48

Abstract:

The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.

US Patent:

8026275, Sep 27, 2011

Filed:

Feb 17, 2006

Appl. No.:

11/816311

Inventors:

Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Vuong Trieu - Calabasas CA, US
Patrick Soon-Shiong - Los Angeles CA, US

Assignee:

Abraxis BioScience, LLC - Los Angeles CA

International Classification:

A01N 43/06
A01N 36/00
A61K 31/12
A61K 31/38

US Classification:

514438, 514675, 514687, 514690

Abstract:

The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.

US Patent:

20070185217, Aug 9, 2007

Filed:

Dec 23, 2004

Appl. No.:

10/584017

Inventors:

Chunlin Tao - Los Angeles CA, US
Cheng Yu - San Diego CA, US
Neil Desai - Santa Monica CA, US
Vuong Trieu - Calabasas CA, US

Assignee:

ABRAXIS BIOSCIENCE, INC. - LOS ANGELES CA

International Classification:

A61K 31/05

US Classification:

514730000, 568017000, 568300000, 568745000

Abstract:

The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.

US Patent:

20090130163, May 21, 2009

Filed:

Feb 21, 2006

Appl. No.:

11/816307

Inventors:

Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Qinwei Wang - Arcadia CA, US
Patrick Soon-Shiong - Los Angeles CA, US

Assignee:

Abraxis Bio Scoence, Inc. - Los Angeles CA

International Classification:

A61F 2/04
A61K 31/337
A61K 31/4375
A61K 31/395
A61K 31/09
C07D 305/08
A61K 31/44
A61K 31/436
A61K 9/00

US Classification:

424423, 514449, 424400, 514283, 514291, 514183, 514355, 514719, 549510

Abstract:

The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.

US Patent:

20100305148, Dec 2, 2010

Filed:

Apr 13, 2010

Appl. No.:

12/759144

Inventors:

Patrick Soon-Shiong - Los Angeles CA, US
Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US

Assignee:

Abraxis BioScience, LLC - Los Angeles CA

International Classification:

A61K 31/4375
C07D 491/22
A61P 35/02
A61P 35/00

US Classification:

514283, 546 48, 977773, 977906

Abstract:

The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.

US Patent:

52788890, Jan 11, 1994

Filed:

Jul 29, 1992

Appl. No.:

7/921862

Inventors:

Andreas C. Papanicolaou - Lincroft NJ
Cheng D. Yu - Scotch Plains NJ

Assignee:

AT&T Bell Laboratories - Murray Hill NJ

International Classification:

H04M 1100

US Classification:

379 53

Abstract:

In a video telephony system, a coaxial cable network, which is preferably a part of an existing cable television system, provides a local link for the transmission of the video telephone signals between each originating and destination location and a respective "head end" located on the cable company premises. Each of the head ends is connected to a "point of presence" of a telephone interexchange carrier so that a connection between pairs of head ends, and thus between a pair of video telephone locations, can be made via a switched digital network maintained by the carrier. Certain of originating and destination locations comprise a standard television set, serving as the audio/video display, and a consumer-type camera or camcorder, serving as the audio/video source. Others of the originating and destination locations comprise ISDN video telephones which are connected to the various points of presence of the interexchange carrier via local exchange carrier telephone networks. The video telephone numbers for cable subscriber locations are administered to be the same as the standard ten- (i. e.

US Patent:

53432401, Aug 30, 1994

Filed:

Nov 4, 1991

Appl. No.:

7/787436

Inventors:

Cheng D. Yu - Scotch Plains NJ

Assignee:

AT&T Bell Laboratories - Murray Hill NJ

International Classification:

H04N 714
H04M 1100

US Classification:

348 14

Abstract:

A system and method for providing two-way video telephony between an originating location and a destination location, each equipped with an audio/video display (television) and an audio/video source (camera) using available channels dedicated for video telephony on one or more coaxial cable distribution networks which can be part of existing cable television systems. Each location is equipped with a network interface unit (NIU) which modulates outgoing audio/video information (which can be in analog or digital form) together with outgoing control messages onto an attached coaxial cable network. The NIU also demodulates incoming audio/video information and incoming control messages received from the attached coaxial network. Upstream signals may be transmitted to a cable network head end and then to the head end serving the destination location using demodulators, A/D converters (if not already in digital form), multiplexers, and the switched digital telecommunications network. If an intra-cable system call is involved, certain processing steps may be eliminated.