Cheryl N Anderson

US Patent:

20100204683, Aug 12, 2010

Filed:

Feb 1, 2008

Appl. No.:

12/524918

Inventors:

Nicholas Bodor - Bal Harbour FL, US
Peter Buchwald - Weston FL, US
Christopher A. Fraker - Hollywood FL, US
Jeffrey Hubbell - Morges, CH
Luca Inverardi - Miami Beach FL, US
Norma Sue Kenyon - Miami FL, US
Paul Latta - Miami FL, US
Antonello Pileggi - Aventura FL, US
Cheryl Stabler Anderson - Coral Gables FL, US
Fabio Grassi - Bellinzona, CH
Camillo Ricordi - Miami FL, US

International Classification:

A61M 5/14

US Classification:

6048911

Abstract:

A device () for receiving implanted biological material includes a mechanoprotective surface () defining an adjacent space, an assembly () for locally delivering media to said space, and a pump or slow/sustained release reservoir structure () operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

US Patent:

20130089594, Apr 11, 2013

Filed:

Apr 12, 2011

Appl. No.:

13/641034

Inventors:

Cheryl Stabler Anderson - Coral Gables FL, US
Eileen Pedraza - Coral Gables FL, US
Christopher A. Fraker - Hollywood FL, US
Peter Buchwald - Weston FL, US
Norma Sue Kenyon - Miami FL, US
Luca Inverardi - Miami Beach FL, US
Antonello Pileggi - Aventura FL, US
Paul Latta - Miami FL, US
Jeffrey Hubbell - Preverenges, CH
Jessica Weaver - Miami FL, US
Camillo D. Ricordi - Miami FL, US

Assignee:

CONVERGE BIOTECH INC. - Miami FL
UNIVERSITY OF MIAMI - Miami FL

International Classification:

A61L 27/18
A61L 27/26

US Classification:

424423, 424 937, 424400

Abstract:

The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets.