Cheryl G Schwartz

US Patent:

50950037, Mar 10, 1992

Filed:

Oct 23, 1990

Appl. No.:

7/604394

Inventors:

Michael A. Goetz - Fanwood NJ
Lawrence R. Koupal - Colonia NJ
Cheryl D. Schwartz - Westfield NJ
Jerrold M. Liesch - Princeton Junction NJ
Otto D. Hensens - Red Bank NJ
Paul S. Anderson - Lansdale PA
Roger Freidinger - Hatfield PA
Douglas J. Pettibone - Chalfont PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3734
C07K 716

US Classification:

514 9

Abstract:

Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.

US Patent:

48596906, Aug 22, 1989

Filed:

Nov 21, 1986

Appl. No.:

6/934212

Inventors:

Raymond S. Chang - Lansdale PA
Otto D. Hensens - Red Bank NJ
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3142

US Classification:

514375

Abstract:

Virginiamycin M. sub. 1 having the Formula: ##STR1## and virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M. sub. 1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M. sub. 1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527.

US Patent:

51890500, Feb 23, 1993

Filed:

Jun 3, 1991

Appl. No.:

7/709676

Inventors:

Roger M. Freidinger - Landsale PA
Mark G. Bock - Hatfield PA
Raymond S. Chang - Lansdale PA
Otto D. Hensens - Red Bank NJ
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3142

US Classification:

514375

Abstract:

Pharmaceutical compositions containing Virginiamycin M. sub. 1 having the Formula: ##STR1## and Virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.

US Patent:

50064665, Apr 9, 1991

Filed:

Oct 26, 1989

Appl. No.:

7/426836

Inventors:

Otto D. Hensens - Red Bank NJ
Raymond S. Chang - Lansdale PA
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12P 1718
C12P 1714
C12N 100
C12N 120

US Classification:

435120

Abstract:

Virginiamycin M. sub. 1 having the Formula: ##STR1## and virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M. sub. 1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M. sub. 1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No.

US Patent:

48943703, Jan 16, 1990

Filed:

Mar 25, 1988

Appl. No.:

7/173342

Inventors:

Raymond S. Chang - Lansdale PA
Otto D. Hensens - Red Bank NJ
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3142
A61K 3133

US Classification:

514183

Abstract:

Virginiamycin M. sub. 1 having the Formula: ##STR1## and virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M. sub. 1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M. sub. 1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No.

US Patent:

47629231, Aug 9, 1988

Filed:

Nov 21, 1986

Appl. No.:

6/934231

Inventors:

Raymond S. Chang - Lansdale PA
Otto D. Hensens - Red Bank NJ
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

C07D49816
A61K 3142
C12P 1714

US Classification:

540455

Abstract:

Virginiamycin M. sub. 1 having the Formula: ##STR1## and virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M. sub. 1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M. sub. 1 and the analogs of Formula I, III, and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No.

US Patent:

57892610, Aug 4, 1998

Filed:

Oct 30, 1996

Appl. No.:

8/741436

Inventors:

Cheryl Faye Schwartz - Bensalem PA

Assignee:

Temple University of the Commonwealth System of Higher Education - Philadelphia PA

International Classification:

G01N 3353

US Classification:

436518

Abstract:

Solid supports for solid phase immunoassays comprise polyethyleneimine-coated negatively charged polymeric materials. The combination of negatively-charged polymer support and polyethyleneimine coating serves to eliminate nonspecific adsorption of biological molecules such as high molecular weight kininogen, which have affinity for solid surfaces and which interfere with immunoassays. The negatively charged polymeric support to which the polyethyleneimine coating is applied may advantageously comprise, for example, a carboxylate-modified styrene microparticle. Antigens or antibodies are coupled by covalent coupling agents to the polyethyleneimine coating to form solid phase immunoreagents. Immunoassays for biological molecules such as high and low molecular weight kininogen are provided.

US Patent:

51379007, Aug 11, 1992

Filed:

Jan 23, 1991

Appl. No.:

7/644755

Inventors:

Raymond S. Chang - Lansdale PA
Otto D. Hensens - Red Bank NJ
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3142

US Classification:

514375

Abstract:

Virginiamycin M. sub. 1 having the Formula: ##STR1## and virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M. sub. 1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M. sub. 1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527.