Cheryl F Schwartz

US Patent:

50950037, Mar 10, 1992

Filed:

Oct 23, 1990

Appl. No.:

7/604394

Inventors:

Michael A. Goetz - Fanwood NJ
Lawrence R. Koupal - Colonia NJ
Cheryl D. Schwartz - Westfield NJ
Jerrold M. Liesch - Princeton Junction NJ
Otto D. Hensens - Red Bank NJ
Paul S. Anderson - Lansdale PA
Roger Freidinger - Hatfield PA
Douglas J. Pettibone - Chalfont PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3734
C07K 716

US Classification:

514 9

Abstract:

Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.

US Patent:

50064665, Apr 9, 1991

Filed:

Oct 26, 1989

Appl. No.:

7/426836

Inventors:

Otto D. Hensens - Red Bank NJ
Raymond S. Chang - Lansdale PA
Cheryl D. Schwartz - Westfield NJ
Deborah L. Zink - Manalapan NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12P 1718
C12P 1714
C12N 100
C12N 120

US Classification:

435120

Abstract:

Virginiamycin M. sub. 1 having the Formula: ##STR1## and virginiamycin M. sub. 1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M. sub. 1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M. sub. 1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No.