Chih K Lee

US Patent:

20210151125, May 20, 2021

Filed:

Jun 19, 2018

Appl. No.:

16/622822

Inventors:

- San Diego CA, US
Jocelyne Bruand - San Diego CA, US
Ryan Matthew Kelley - San Diego CA, US
Chih Lee - San Diego CA, US
Konrad Scheffler - San Diego CA, US

International Classification:

G16B 30/00
G16B 20/20
G16B 5/20

Abstract:

Methods and systems are provided for quantifying and deconvolving nucleic acid mixture samples including nucleic acid of one or more contributors having known or unknown genomes. The methods and systems provided herein implement processes that use Bayesian probabilistic modeling techniques to determine the abundances and confidence intervals of genetically distinct contributors in a chimerism sample, thereby improving specificity, accuracy and sensitivity, and greatly expanded the application scope over conventional methods.

US Patent:

20190325990, Oct 24, 2019

Filed:

Jan 7, 2019

Appl. No.:

16/241288

Inventors:

- San Diego CA, US
Jocelyn BRUAND - San Diego CA, US
Ryan Matthew KELLEY - San Diego CA, US
Chih LEE - San Diego CA, US
Eric ALLEN - San Diego CA, US
Youting SUN - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

G16B 30/10

Abstract:

Provided is a computer-implemented method of aligning RNA including receiving onto a data storage unit primer sequences and transcript sequences transcribable from a reference genome based on a gene model, generating target sequences to be amplified from a combination of the primer sequences and the transcript sequences, generating a modified reference genome based on the plurality of target sequences, aligning sequence reads generated from a test sample comprising RNA amplicon molecules to the of target sequences, and generating an alignment profile for the test sample based on the aligning. Also provided is a computer system for performing the foregoing method.