Chintamani P Bapat

US Patent:

52254275, Jul 6, 1993

Filed:

Nov 27, 1991

Appl. No.:

7/799179

Inventors:

Bindumadhavan Venugopalan - Thane, Maharashtra, IN
Chintamani P. Bapat - Urbana IL
Pravin J. Karnik - Thane, IN
Bansi Lal - Bombay, IN
Dipak K. Chatterjee - Bombay, IN
Subramani N. Iver - Bombay, IN
Richard H. Rupp - Konigstein/Taunus, DE

Assignee:

Hoechst Aktiengesellschaft - Frankfurt am Main

International Classification:

A61K 31335
C07D49318

US Classification:

514378

Abstract:

10-substituted ether derivatives of 3. alpha. , 12. alpha. -Epoxy-3,4,5 5a. alpha. , 6,7,8,8a. alpha. ,9,10,12. beta. , 12a-dodecahydro-10-hydroxy-3. beta. ,6. alpha. ,9. beta. -trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroquinghaosu (DHQ), pharmaceutically acceptable salts thereof, processes for their preparation and their use as chemotherapeutics against protozoal infections are provided.