Chittari Pabba

US Patent:

20130071332, Mar 21, 2013

Filed:

Sep 16, 2011

Appl. No.:

13/234210

Inventors:

Jack Mathew Webster - Colonie NY, US
Bruce Fletcher Johnson - Scotia NY, US
Brian Duh-Lan Lee - Rexford NY, US
Chittari Pabba - Slingerlands NY, US
Michael James Rishel - Saratoga Springs NY, US

Assignee:

GENERAL ELECTRIC COMPANY - Schenectady NY

International Classification:

A61K 49/04
A61P 43/00
A61K 49/00
C07C 55/02
C12Q 1/02

US Classification:

424 94, 562596, 435 29, 424 91

Abstract:

Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

US Patent:

20070160622, Jul 12, 2007

Filed:

Dec 7, 2006

Appl. No.:

11/636230

Inventors:

William Turnell - Del Mar CA, US
Benjamin Parcher - San Diego CA, US
Catherine Charles - Encinitas CA, US
Chittari Pabba - San Diego CA, US
Maria Vitiello - La Jolla CA, US

Assignee:

MediVas, LLC - San Diego CA

International Classification:

A61K 39/145
A61K 39/00
A61K 47/48
C08F 20/00
C08G 63/91

US Classification:

424185100, 525054100, 525440000, 424078270, 424209100

Abstract:

A one-step method for assembly of delivery compositions for one or more antigens or therapeutic biologics is based on non-covalent affinity capture of molecules from solution using a biodegradable polymer having functional groups to which the affinity ligand binds. The polymer-bound affinity complex, which includes the molecule(s) of interest is then recovered from the reaction solution, for example, by size exclusion filtration, to yield the assembled delivery composition. The affinity ligand can be a monoclonal antibody or a metal affinity ligand with bound metal transition ion. The assembled delivery compositions can be formulated as polymer particles, which can then be lyophilized and reconstituted for in vivo delivery of the non-covalently complexed antigen(s) or therapeutic biologic(s) with substantial native activity.

US Patent:

20210053984, Feb 25, 2021

Filed:

Feb 27, 2020

Appl. No.:

16/802654

Inventors:

- Pembroke, BM
Claudio Chuaqui - Arlington MA, US
John Malona - Brookline MA, US
Joseph John McDonald - Sudbury MA, US
Yike Ni - Lexington MA, US
Deqiang Niu - Lexington MA, US
Russell C. Petter - Stow MA, US
Juswinder Singh - Southborough MA, US
Chittari Pabba - Slingerlands NY, US

International Classification:

C07D 495/14
A61P 37/00
A61P 35/00

Abstract:

The present invention provides compounds, compositions thereof, and methods of using the same.

US Patent:

20190375762, Dec 12, 2019

Filed:

Apr 4, 2019

Appl. No.:

16/375317

Inventors:

- Pembroke, BM
Claudio Chuaqui - Arlington MA, US
John Malona - Brookline MA, US
Joseph John McDonald - Sudbury MA, US
Yike Ni - Lexington MA, US
Deqiang Niu - Lexington MA, US
Russell C. Petter - Stow MA, US
Juswinder Singh - Southborough MA, US
Chittari Pabba - Slingerlands NY, US

International Classification:

C07D 495/14

Abstract:

The present invention provides compounds, compositions thereof, and methods of using the same.

US Patent:

20170114073, Apr 27, 2017

Filed:

Sep 29, 2016

Appl. No.:

15/280157

Inventors:

- Cambridge MA, US
Claudio Chuaqui - Arlington MA, US
John Malona - Brookline MA, US
Joseph John McDonald - Sudbury MA, US
Yike Ni - Lexington MA, US
Deqiang Niu - Lexington MA, US
Russell C. Petter - Stow MA, US
Juswinder Singh - Southborough MA, US
Chittari Pabba - Slingerlands NY, US

International Classification:

C07D 495/14

Abstract:

The present invention provides compounds, compositions thereof, and methods of using the same.