Chiu S Chang

US Patent:

7560239, Jul 14, 2009

Filed:

Jun 4, 2002

Appl. No.:

10/163018

Inventors:

Marie Lin - Cupertino CA, US
Tom Chia - Cupertino CA, US
Chiu Chin Chang - Sunnyvale CA, US

Assignee:

Lin-Zhi International Inc. - Sunnyvale CA

International Classification:

G01N 33/00

US Classification:

435 71, 435 74, 435 79, 435 792, 435 793, 435 26, 436501, 436518, 436536, 4241301

Abstract:

Methods and kits are provided for the simultaneous detection of multiple analytes, i. e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly the plurality of analytes are structurally unrelated or significantly different, particularly to whether one or more of such analytes is present in a sample in a concentration that is above a predetermined minimum or cutoff value, and particularly for such analytes with different cutoffs. The methods and kits are particularly useful for-screening for the presence of a plurality of drugs (licit and/or illicit), performance-enhancing substances, and other chemicals, and involve a competitive enzyme immunoassay employing one or more conjugates of G6PDH with a plurality of the analytes.

US Patent:

8344115, Jan 1, 2013

Filed:

Apr 17, 2009

Appl. No.:

12/385749

Inventors:

Chiu Chin Chang - Sunnyvale CA, US

International Classification:

C07K 16/00
G01N 33/532

US Classification:

5303898, 5303889, 5303913, 436544

Abstract:

This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention is particularly suited for the detection of S-adenosylmethionine in the presence of S-adenosylhomocysteine, other nucleosides and derivatives in a biological sample. The methods of this invention involve an antibody produced specifically against S-adenosylmethionine; particularly, analogs modified strategically at the sulfonium position. An assay protocol comprises chemically modified analyte analog linked to an enzymatic reporter and the aforementioned antibody was used to demonstrate the assay specificity and sensitivity. Additional assay method with immobilized immunogen, the specific antibody, and an enzyme labeled secondary antibody was also described for illustration. The invention also features hapten design and novel compounds used as haptens to prepare immunogen and for the specific antibody production.

US Patent:

48574554, Aug 15, 1989

Filed:

Nov 26, 1982

Appl. No.:

6/444658

Inventors:

Pyare L. Khanna - San Jose CA
Chiu C. Chang - Santa Clara CA
Edwin F. Ullman - Atherton CA

Assignee:

Syntex (U.S.A) Inc. - Palo Alto CA

International Classification:

G01N 33535
C12Q 126
C12Q 128
C12N 996

US Classification:

435 7

Abstract:

Novel fluorogenic peroxidase substrates are provided employing novel water soluble activated capped aromatic fluorescent compounds for use as peroxidase substrates. The novel compounds can be used in a wide variety of ways for determination of peroxides, peroxidase, and in assays for analytes employing peroxidase as a label on a member of a specific binding pair.

US Patent:

54162149, May 16, 1995

Filed:

Mar 29, 1994

Appl. No.:

8/219323

Inventors:

John Pease - Los Altos CA
Thomas L. Tarnowski - San Francisco CA
Donald Berger - San Jose CA
Chiu C. Chang - Sunnyvale CA
Chun-Hua Chuang - Akron OH

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D51900

US Classification:

546 94

Abstract:

Novel squaraine dyes and compositions of matter containing such dyes are disclosed. The novel squaraine dyes have an absorption maximum greater than 600 nanometers and are particularly useful in conjunction with a helium/neon (He/Ne) laser. Some of the squaraine dyes are hydrophilic and are therefore water soluble or water compatible and others of the squaraine dyes are lipophilic.

US Patent:

50398180, Aug 13, 1991

Filed:

Jan 23, 1989

Appl. No.:

7/300996

Inventors:

John Pease - Los Altos CA
Thomas L. Tarnowski - San Francisco CA
Donald Berger - San Jose CA
Chiu C. Chang - Sunnyvale CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D40308

US Classification:

548409

Abstract:

Squaraine dyes and compositions of matter containing such dyes are disclosed. The squaraine dyes have an absorption maximum greater than 600 nanometers and are particularly useful in conjunction with a helium/neon (He/Ne) laser. Some of the squaraine dyes are hydrophilic and are therefore water soluble or water compatible and others of the squaraine dyes are lipophilic.

US Patent:

53290194, Jul 12, 1994

Filed:

Apr 27, 1992

Appl. No.:

7/874659

Inventors:

John Pease - Los Altos CA
Thomas L. Tarnowski - San Francisco CA
Donald Berger - San Jose CA
Chiu C. Chang - Sunnyvale CA
Chun-Hua Chuang - Akron OH

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D40308

US Classification:

548455

Abstract:

Novel squaraine dyes and compositions of matter containing such dyes are disclosed. The novel squaraine dyes have an absorption maximum greater than 600 nanometers and are particularly useful in conjunction with a helium/neon (He/Ne) laser. Some of the squaraine dyes are hydrophilic and are therefore water soluble or water compatible and others of the squaraine dyes are lipophilic.

US Patent:

48307866, May 16, 1989

Filed:

Feb 27, 1986

Appl. No.:

6/834168

Inventors:

John Pease - Los Altos CA
Thomas L. Tarnowski - San Francisco CA
Donald Berger - San Jose CA
Chiu C. Chang - Sunnyvale CA
Chun-Hua Chuang - Akron OH

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07C 8714
C07D20746
C07D29522

US Classification:

260396N

Abstract:

Squaraine dyes and compositions of matter containing such dyes are disclosed. The squaraine dyes have an absorption maximum greater than 600 nanometers and are particulary useful in conjunction with a helium/neon (He/Ne) laser. Some of the squaraine dyes are hydrophilic and are therefore water soluble or water compatible and others of the squaraine dyes are lipophilic.

US Patent:

47481293, May 31, 1988

Filed:

Aug 28, 1984

Appl. No.:

6/645458

Inventors:

Chiu C. Chang - Sunnyvale CA
Vartan Ghazarossian - Palo Alto CA
Edwin F. Ullman - Atherton CA

Assignee:

Snytex (U.S.A.) Inc. - Palo Alto CA

International Classification:

G01N 33554
G01N 33555

US Classification:

436519

Abstract:

A method is provided for determining the presence in a sample of a member of a specific binding pair ("sbp member") consisting of ligand and its homologous receptor. The sample is combined in an aqueous medium with (1) a complementary sbp member wherein at least the sbp member or the complementary sbp member is bound to the surface of a cell and (2) a fuorescent agent capable of being incorporated into the cell. The presence of the sbp member is indicated by a change in fluorescence of the unseparated cell suspension as a result of agglutination of the cells. The present invention has particular application to blood typing, for example, for the determination of the presence of blood group antigens A, B, AB, O, and D (Rh. sub. o) and antibodies to such antigens.