Christine E Craig

US Patent:

20200405779, Dec 31, 2020

Filed:

Feb 28, 2019

Appl. No.:

16/976721

Inventors:

- Baltimore MD, US
Christine Craig - Baltimore MD, US
Drew M. Pardoll - Brookeville MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 35/741
A61P 35/00
G01N 33/569
C12Q 1/689

Abstract:

Compositions for the treatment of colorectal cancer target bacterial biofilms in the gastrointestinal tract. Methods of treatment include one or more agents which target bacteria and the bacterial biofilms.

US Patent:

20190265245, Aug 29, 2019

Filed:

Dec 31, 2018

Appl. No.:

16/237112

Inventors:

- Baltimore MD, US
Drew M. Pardoll - Brookeville MD, US
Christine Craig - Baltimore MD, US
Elizabeth Wick - Baltimore MD, US

International Classification:

G01N 33/574
A61K 45/06
A61K 31/7056
A61K 35/745
A61K 35/747
C12Q 1/6869
C12Q 1/6841
A61K 31/407
A61K 35/741
A61K 35/742
A61K 35/744
A61K 31/7048
A61K 31/546
A61K 31/43
A61K 31/165

Abstract:

Methods of identifying subjects at increased risk of cancer, based upon detection of biofilms and/or biofilm-associated microbes within a subject, are disclosed. Therapies designed to prevent formation and/or reduce the size of biofilms in a subject identified to be at increased risk of cancer based upon detection of biofilms and/or biofilm-associated microbes are disclosed. In particular embodiments, the invention provides for identification of a subject at elevated risk of developing or having colorectal cancer and/or a colorectal adenoma, based upon detection of a biofilm and/or biofilm-associated bacteria within the gastrointestinal tract of the subject (optionally, within a biopsy specimen and/or stool sample of such subject). Therapies involving administration of an antibiotic agent and/or a probiotic agent to a subject, to prevent or reduce biofilm formation within the gastrointestinal tract of the subject, optionally provided in combination with additional cancer therapy, are also disclosed.