Christine G Garcia

US Patent:

6465196, Oct 15, 2002

Filed:

Mar 13, 2001

Appl. No.:

09/804778

Inventors:

Helen H. Hobbs - Dallas TX
Christine K. Garcia - Dallas TX
Robert I. Barnes - Frisco TX
Jonathan Cohen - Dallas TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 3353

US Classification:

435 71, 435 6, 436501

Abstract:

Low density lipoprotein receptor (LDRL) adaptin is a novel, key component of human cholesterol regulation, which provides a target for rational drug design and screening, therapeutic intervention, and diagnosis. Disclosed reagents include a variety of LDLR adaptin and LDLR adaptin PTB and CC domain compositions, including in vitro compositions comprising a natural human LDLR adaptin PTB domain and a ligand such as an NPXY (SEQ ID NO:7) peptide. These LDLR adaptin reagents are used, inter alia, in rational drug screening methods. The invention also provides polynucleotides encoding the subject LDLR adaptin polypeptides, including natural coding sequences, which may be used as probes or primers for detecting or amplifying LDLR adaptin genes and transcripts.

Address:

1209 Alder Dr APT 1704, Arlington, TX 76012

VIN:

4A3AB36F37E045813

Make:

MITSUBISHI

Model:

GALANT

Year:

2007