Christine T Morrison

US Patent:

6370189, Apr 9, 2002

Filed:

May 27, 1998

Appl. No.:

09/085435

Inventors:

Christine J. Morrison - Decatur GA
Errol Reiss - Chamblee GA
Liliana Aidorevich - Maracay Edo Aragua, VE
Jong Soo Choi - Taegu, KR

Assignee:

Ericsson Inc. - Research Triangle Park NC

International Classification:

H04B 346

US Classification:

375224, 375341, 714794

Abstract:

The present invention provides apparatus and methods in which variable delay is provided for channel tracking. In particular, a demodulator having both a hard output (or symbol estimate) and a soft output (or indication of the quality of the symbol estimate) is coupled to a channel tracker. The channel tracker provides a channel estimate used by the demodulator, in part, to correct for fading. The channel tracker updates the channel estimate based on the symbol estimates from the demodulator and the received signal. However, when the soft output indicates a low confidence in the symbol estimate, the symbol estimate is not used to update the channel estimate. This is accomplished by providing a variable delay to the channel estimate calculation performed by the channel tracker depending on the number of consecutive suspect symbol estimates. For example, a single suspect estimate generates a delay of one causing the most recent estimate to not be used, two consecutive suspect estimate generates a delay of two causing the two most recent estimates to not be used and so on. Accordingly, the channel tracker of the present invention utilizes only the most reliable data available locally to generate a channel estimate for use by the demodulator.

US Patent:

6372430, Apr 16, 2002

Filed:

Jun 27, 2000

Appl. No.:

09/423233

Inventors:

Christine J. Morrison - Decatur GA
Errol Reiss - Chamblee GA
Liliana Aidorevich - Maracay Edo Aragun, VE
Jong Soo Choi - Taegu, KR

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 536 231, 536 2432, 536 243, 536 237

Abstract:

Nucleic acids for detecting Aspergillus species and other filamentous fungi are provided. Unique internal transcribed space 2 coding regions permit the development of nucleic acid probes specific for five different species of Aspergillus, three species of Fusarium, four species of Mucor, two species of Penecillium, five species of Rhizopus, one species of Rhizomucor, as well as probes for , and. Methods are disclosed for the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, , Cunninghaemella, Pseudallescheria or Sporthrix in a subject. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an all-fungus nucleic acid probe.

US Patent:

7052836, May 30, 2006

Filed:

Jan 14, 2002

Appl. No.:

10/046955

Inventors:

Christine J. Morrison - Decatur GA, US
Errol Reiss - Chamblee GA, US
Jong Soo Choi - Taegu, KR
Liliana Aidorevich - Maracay Edo Aragua, VE

Assignee:

The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

435 6, 435 911, 435 912, 536 231, 536 2432

Abstract:

Nucleic acids for detecting species and other filamentous fungi are provided. Unique internal transcribed space 2 coding regions permit the development of nucleic acid probes specific for five different species of , three species of , four species of , two species of , five species of , one species of , as well as probes for , and. Methods are disclosed for the species-specific detection and diagnosis of infection by or in a subject. Furthermore, genus-specific probes are also provided for and , in addition to an all-fungus nucleic acid probe.

US Patent:

7384741, Jun 10, 2008

Filed:

May 16, 2003

Appl. No.:

10/514861

Inventors:

Christine J. Morrison - Decatur GA, US
Hans Peter Hinrikson - Wallisellen, CH

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 6, 435 912, 536 237, 536 2432

Abstract:

Novel techniques for the detection of in samples are disclosed. These techniques relate to PCR amplification and/or detection of ITS1 rDNA sequences, and the identification of particular species of by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, , and. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as CBS 119. 5A, strain NRRL 1932, strain NRRL 250, strain NRRL 4768, strain CUHI, strain CUH2, strain CUH7, and strain CUH8.

US Patent:

7427472, Sep 23, 2008

Filed:

Sep 25, 2002

Appl. No.:

10/490726

Inventors:

Mark D. Lindsley - Lawrenceville GA, US
Zhenyu Qin - Atlanta GA, US
Christine J. Morrison - Decatur GA, US
Jong S. Choi - Daegu, KR

Assignee:

United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 6, 435 912, 536 2432, 536 2433

Abstract:

Methods of detecting a dimorphic fungus, including differentiating a dimorphic fungus from other fungi are disclosed. A sample suspected of containing a nucleic acid of a fungus, such as an internal transcribed spacer-2 (ITS2) nucleic acid sequence of a dimorphic fungal rDNA, is screened for the presence or absence of that nucleic acid. The presence of the nucleic acid indicates the sample was contacted by the fungus. Determining whether the nucleic acid sequence is present in the sample can be accomplished by detecting hybridization between a dimorphic probe, species-specific probe, and/or microbe-specific probe and a nucleic acid sequence corresponding to the ITS2 region of fungal rDNA. Kits and arrays for carrying out these methods also are disclosed.

US Patent:

7871779, Jan 18, 2011

Filed:

May 5, 2008

Appl. No.:

12/115493

Inventors:

Christine J. Morrison - Decatur GA, US
Hans Peter Hinrikson - Wallisellen, CH

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 6, 435 912, 536 237, 536 2432

Abstract:

Novel techniques for the detection of in samples are disclosed. These techniques relate to PCR amplification and/or detection of ITS1 rDNA sequences, and the identification of particular species of by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, , and. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as CBS 119. 5A, strain NRRL 1932, strain NRRL 250, strain NRRL 4768, strain CUHI, strain CUH2, strain CUH7, and strain CUH8.

US Patent:

8119788, Feb 21, 2012

Filed:

Sep 26, 2006

Appl. No.:

12/088235

Inventors:

Christine J. Morrison - Decatur GA, US
Sanchita Das - New York NY, US
Teresa Brown - Lawrenceville GA, US
Brian Holloway - Atlanta GA, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC

International Classification:

C40B 40/06

US Classification:

536 2432, 536 231, 506 16

Abstract:

Compositions and methods for detecting and/or differentiating among organisms, including and , are disclosed. Exemplary methods involve screening a sample suspected of containing at least one or more sp. for the presence or absence of a nucleic acid sequence specific for each such fungal pathogen. Some disclosed methods permit the rapid and simultaneous detection and identification of several fungal pathogens (e. g. , up to 100 fungi) in a single sample.

US Patent:

56459920, Jul 8, 1997

Filed:

Apr 26, 1995

Appl. No.:

8/429522

Inventors:

Timothy J. Lott - Atlanta GA
Christine J. Morrison - Atlanta GA
Errol Reiss - Chamblee GA
Brent Lasker - Atlanta GA
Sandra Zakroff - Clarkston GA

Assignee:

The United States of America As Represented By The Secretary of Health
and Human Services - Washington DC

International Classification:

C12Q 168
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

Provided is an isolated double-stranded nucleic acid consisting essentially of the nucleotide sequences defined in the Sequence Listing by SEQ ID Nos: 5-9. These are the ITS2 sequences for C. albicans, C. parapsilosis, C. tropicalis, C. glabrata and C. krusei. A method of diagnosing systemic candidiasis in a subject is also provided. The method comprises the steps of: (a) collecting blood from the subject into tubes containing detergent, polypropylene glycol, sodium poyantholesulfonate, and sodium ethylene diamine tetraacetic acid; (b) lysing Candida cells using ZYMOLYASE. RTM. -100T with agitation; (c) extracting and precipitating the DNA from the lysed cells; (d) amplifying the precipitated DNA using universal fungal primer pairs derived from the internal transcribed spacer regions of the Candida ribosomal DNA; and (e) detecting amplified DNA from Candida by hybridizing the amplified DNA with a probe that selectively hybridizes with Candida DNA, the presence of amplified DNA indicating systemic candidiasis.