Christine E Schmidt

US Patent:

6696575, Feb 24, 2004

Filed:

Mar 27, 2002

Appl. No.:

10/107705

Inventors:

Christine E. Schmidt - Austin TX
Tyrell J. Rivers - Elkins Park PA

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D29500

US Classification:

548524, 252500

Abstract:

The subject matter of the present invention includes a novel biodegradable conducting polymer for biomedical applications. The polymer combines mixed heteroaromatic conductive segments of pyrrole and thiophene with flexible aliphatic chains via degradable ester linkages. In addition to its utility for peripheral nerve regeneration, the polymer may be applied to other areas of tissue engineering, including spinal cord regeneration, wound healing, bone repair, muscle tissue stimulation, and other regenerative, restorative, reconstructive, therapeutic, prophylactic, and diagnostic functions.

US Patent:

7402319, Jul 22, 2008

Filed:

Sep 26, 2003

Appl. No.:

10/672689

Inventors:

Christine Schmidt - Austin TX, US
Terry Hudson - Barboursville VA, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61F 2/02

US Classification:

424422, 424484, 623 1111, 623 2372

Abstract:

The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and/or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications.

US Patent:

7598344, Oct 6, 2009

Filed:

Sep 4, 2003

Appl. No.:

10/654623

Inventors:

Angela M. Belcher - Lexington MA, US
Christine J. Schmidt - Austin TX, US
Kiley P. H. Miller - Somerville MA, US
Archit Sanghvi - Austin TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07K 7/00
C08G 63/48
C08G 63/91
A61K 38/31

US Classification:

530327, 530324, 530325, 530326, 530350, 530808, 530815, 536 231, 525 541

Abstract:

The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.

US Patent:

20090030269, Jan 29, 2009

Filed:

Jun 9, 2008

Appl. No.:

12/135772

Inventors:

Christine Schmidt - Austin TX, US
Terry Hudson - San Clemente CA, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61F 2/04
A61F 2/02

US Classification:

600 36, 623 2372

Abstract:

The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and/or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications.

US Patent:

20100113741, May 6, 2010

Filed:

Aug 11, 2009

Appl. No.:

12/461436

Inventors:

Angela M. Belcher - Lexington MA, US
Christine J. Schmidt - Austin TX, US
Kiley P. H. Miller - Somerville MA, US
Archit Sanghvi - Austin TX, US

International Classification:

C07K 1/00

US Classification:

530333

Abstract:

The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.

US Patent:

20110008442, Jan 13, 2011

Filed:

Feb 26, 2009

Appl. No.:

12/919667

Inventors:

Scott Zawko - College Station TX, US
Christine E. Schmidt - Austin TX, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61K 9/14
B29C 71/02
B29C 71/04

US Classification:

424486, 264236, 264425, 424488

Abstract:

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

US Patent:

20120088735, Apr 12, 2012

Filed:

Oct 7, 2011

Appl. No.:

13/269366

Inventors:

Sarah Mayes - Austin TX, US
Christine E. Schmidt - Austin TX, US

Assignee:

The Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/738
B29C 35/08

US Classification:

514 54, 264425

Abstract:

The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

US Patent:

20120088832, Apr 12, 2012

Filed:

Oct 7, 2011

Appl. No.:

13/269344

Inventors:

Sarah Mayes - Austin TX, US
Christine E. Schmidt - Austin TX, US
Daniel Peterson - Austin TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 47/36
A61K 31/195
A61K 31/192
A61P 7/00
A61P 17/02
A61P 25/00
A61P 19/00
A61P 9/00
B29C 35/08
A61K 47/42

US Classification:

514561, 264425, 514570, 514773, 514774, 514777, 514779

Abstract:

A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.