Christine Yang

US Patent:

20210346344, Nov 11, 2021

Filed:

Jul 26, 2021

Appl. No.:

17/385194

Inventors:

- Rahway NJ, US
Ginny Dai HO - Murray Hill NJ, US
Sookhee N. HA - Warren NJ, US
Sandra J. KOSEOGLU - Fanwood NJ, US
Marc A. LABROLI - West Point PA, US
Sang Ho LEE - Berkeley Heights NJ, US
Mihir MANDAL - Westfield NJ, US
Jianping PAN - Monmouth Junction NJ, US
Weidong PAN - Hillsborough NJ, US
Terry ROEMER - Cranford NJ, US
Jing SU - Scotch Plains NJ, US
Christopher Michael TAN - Scotch Plains NJ, US
Zheng TAN - Westfield NJ, US
Hao WANG - Scotch Plains NJ, US
Christine YANG - New Brunswick NJ, US
Shu-Wei YANG - Edison NJ, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

A61K 31/397
A61P 31/04
A61K 31/407
C07D 235/08
C07D 401/04
C07D 401/14
C07D 403/04
C07D 403/06
C07D 471/04

Abstract:

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

US Patent:

20210346364, Nov 11, 2021

Filed:

Jul 26, 2021

Appl. No.:

17/385258

Inventors:

- Rahway NJ, US
Reynalda DE JESUS - East Brunswick NJ, US
Charles J. GIll - Beachwood NJ, US
Ginny Dai HO - Murray Hill NJ, US
Sookhee N. HA - Warren NJ, US
Sandra J. KOSEOGLU - Fanwood NJ, US
Marc A. LABROLI - West Point PA, US
Sang Ho LEE - Berkeley Heights NJ, US
Mihir MANDAL - Westfield NJ, US
Terry ROEMER - Cranford NJ, US
Jing SU - Scotch Plains NJ, US
Christopher Michael TAN - Scotch Plains NJ, US
Zheng TAN - Westfield NJ, US
Haifeng TANG - Metuchen NJ, US
Hao WANG - Scotch Plains NJ, US
Christine YANG - New Brunswick NJ, US
Shu-Wei YANG - Edison NJ, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

A61K 31/4439
A61P 31/04
A61K 31/407
A61K 31/421
A61K 31/422
A61K 31/427
A61K 31/431
A61K 31/4375
A61K 31/438
A61K 31/4709
A61K 31/5377
A61K 31/5383
C07D 263/26
C07D 413/04
C07D 413/06
C07D 413/12
C07D 413/14
C07D 417/12
C07D 471/04
C07D 491/048
C07D 495/04
C07D 498/04

Abstract:

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

US Patent:

20200261410, Aug 20, 2020

Filed:

Dec 13, 2016

Appl. No.:

16/061481

Inventors:

- Rahway NJ, US
Ginny Dai HO - Murray Hill NJ, US
Sookhee N. HA - Warren NJ, US
Sandra J. KOSEOGLU - Fanwood NJ, US
Marc A. LABROLI - West Point PA, US
Sang Ho LEE - Berkeley Heights NJ, US
Mihir MANDAL - Westfield NJ, US
Jianping PAN - Monmouth Junction NJ, US
Weidong PAN - Hillsborough NJ, US
Terry ROEMER - Cranford NJ, US
Jin SU - Scotch Plains NJ, US
Christopher Michael TAN - Scotch Plains NJ, US
Zheng TAN - Westfield NJ, US
Hao WANG - Scotch Plains NJ, US
Christine YANG - New Brunswick NJ, US
Shu-Wei YANG - Edison NJ, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

A61K 31/397
C07D 235/08
C07D 471/04
C07D 403/04
C07D 403/06
C07D 401/14
C07D 401/04
A61K 31/407
A61P 31/04

Abstract:

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

US Patent:

20200261436, Aug 20, 2020

Filed:

Dec 13, 2016

Appl. No.:

16/061519

Inventors:

- Rahway NJ, US
Reynalda DE JESUS - East Brunswick NJ, US
Charles J. GIll - Beachwood NJ, US
Ginny Dai HO - Murray Hill NJ, US
Sookhee N. HA - Warren NJ, US
Sandra J. KOSEOGLU - Fanwood NJ, US
Marc A. LABROLI - West Point PA, US
Sang Ho LEE - Berkeley Heights NJ, US
Mihir MANDAL - Westfield NJ, US
Terry ROEMER - Cranford NJ, US
Jing SU - Scotch Plains NJ, US
Christopher Michael TAN - Scotch Plains NJ, US
Zheng TAN - Westfield NJ, US
Haifeng TANG - Metuchen NJ, US
Hao WANG - Scotch Plains NJ, US
Christine YANG - New Brunswick NJ, US
Shu-Wei YANG - Edison NJ, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

A61K 31/4439
A61K 31/407
A61K 31/431
C07D 413/12
C07D 471/04
C07D 263/26
C07D 495/04
C07D 491/048
C07D 417/12
C07D 413/14
C07D 413/06
C07D 413/04
C07D 498/04
A61K 31/4709
A61K 31/438
A61K 31/421
A61K 31/4375
A61K 31/422
A61K 31/427
A61K 31/5377
A61K 31/5383
A61P 31/04

Abstract:

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

US Patent:

20140256723, Sep 11, 2014

Filed:

Oct 8, 2012

Appl. No.:

14/350888

Inventors:

- Rahway NJ, US
Christine Yang - Jersey City NJ, US
Jason M. Cox - East Windsor NJ, US
Kun Liu - Needham MA, US

International Classification:

C07D 413/04
A61K 31/4439
A61K 31/5377
A61K 31/506
A61K 31/422
C07D 413/14

US Classification:

5142345, 548226, 514376, 544137, 544333, 514256, 5462714, 514338

Abstract:

The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above-mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).