Christopher J Bergeron

US Patent:

20220362311, Nov 17, 2022

Filed:

Jun 19, 2020

Appl. No.:

17/621121

Inventors:

- Cambridge MA, US
- Boston MA, US
Philippa Jane Reeder Morrison - Arlington MA, US
Christopher George Bergeron - Fitchburg MA, US
Dylan Alexander Carlin - Jamaica Plain MA, US
Laura K. Stone - Cambridge MA, US
Alex C. Tucker - Dorchester MA, US
Patrick M. Boyle - Boston MA, US

International Classification:

A61K 35/747
A61K 35/741
A61K 35/745
A61K 35/742
A61K 35/744
A61P 13/02
C12N 1/20
C12N 15/52
C12N 15/70

Abstract:

The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding an improved leucine catabolism enzyme with higher activity and/or specificity for leucine over other branched chain amino acids, such as isoleucine or valine. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of leucine, isoleucine, and/or valine using the pharmaceutical compositions disclosed herein.

US Patent:

20230105474, Apr 6, 2023

Filed:

Feb 25, 2021

Appl. No.:

17/801854

Inventors:

- Cambridge MA, US
Sean Cotton - Somerville MA, US
Jian-Rong Gao - Malden MA, US
Teodelinda Mirabella - Boston MA, US
Christopher George Bergeron - Fitchburg MA, US

International Classification:

A61K 35/74
C12N 15/63
C12N 9/06
C12N 15/70
A61K 38/44
A61P 19/06

Abstract:

The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient's internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells that comprise a uric acid catabolism enzyme, e.g., a uric acid degrading enzyme, for the treatment of diseases and disorders associated with uric acid, including hyperuricemia and gout, in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with uric acid, such as hyperuricemia.

US Patent:

20200190462, Jun 18, 2020

Filed:

Feb 26, 2020

Appl. No.:

16/802543

Inventors:

- Wakefield MA, US
Thomas Craig Masterman - Rockport MA, US
Aiichiro Yoshida - Canton MA, US
Jaewoong Moon - Andover MA, US
Christopher G. Bergeron - Fitchburg MA, US
James J. Lynch - Woburn MA, US

International Classification:

C12N 1/14
C12N 1/38
C12N 1/22
C12N 9/42
C12P 19/02
C12P 19/14

Abstract:

The present invention relates to compositions to induce production of proteins, e.g., enzymes, e.g., amylases or biomass degrading enzymes in a host cell, and methods for increasing the yield of the proteins, e.g., enzymes produced. Such compositions comprise a caramelized sugar product. The methods described herein can also be used to enhance processing of biomass materials, e.g., to produce sugar products.

US Patent:

20180010088, Jan 11, 2018

Filed:

Mar 30, 2016

Appl. No.:

15/031439

Inventors:

- Wakefield MA, US
Thomas Craig Masterman - Rockport MA, US
Aiichiro Yoshida - Canton MA, US
Jaewoong Moon - Andover MA, US
Christopher G. Bergeron - Fitchburg MA, US
James J. Lynch - Woburn MA, US

International Classification:

C12N 1/14
C12P 19/02
C12N 9/42
C12P 19/14
C12N 1/38

Abstract:

The present invention relates to compositions to induce production of proteins, e.g., enzymes, e.g., amylases or biomass degrading enzymes in a host cell, and methods for increasing the yield of the proteins, e.g., enzymes produced. Such compositions comprise a caramelized sugar product. The methods described herein can also be used to enhance processing of biomass materials, e.g., to produce sugar products.

US Patent:

20160053047, Feb 25, 2016

Filed:

May 16, 2014

Appl. No.:

14/758893

Inventors:

- Woburn MA, US
Thomas Craig MASTERMAN - Rockport MA, US
Jaewoong MOON - Andover MA, US
Christopher G. BERGERON - Fitchburg MA, US

International Classification:

C08G 63/685
B01J 19/24
C07C 229/24
C12P 13/20
C12P 13/14

Abstract:

Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as amino-alpha, omega-dicarboxylic acid and amino-alpha, omega-dicarboxylic acid derivatives. These products include polymers and copolymers of alpha-amino, omega-dicarboxylic acids.