Christopher J Cannizzaro

US Patent:

20120123519, May 17, 2012

Filed:

Aug 11, 2008

Appl. No.:

12/672521

Inventors:

Michael L. Lovett - Medford MA, US
Xianyan Wang - US MA, US
Christopher M. Cannizzaro - Washington DC, US
David L. Kaplan - Concord MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
TRUSTEES OF TUFTS COLLEGE - Medford MA

International Classification:

A61F 2/82
B29C 41/14
B32B 1/08

US Classification:

623 115, 428 341, 26417126, 26417112

Abstract:

Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.

US Patent:

20070128087, Jun 7, 2007

Filed:

Aug 13, 2004

Appl. No.:

10/569114

Inventors:

Christopher Cannizzaro - Cambridge MA, US
Urs Von Stockar - Lutry, CH

Assignee:

ISMATEC SA, LABORATORIUMSTECHNIK - Glattbrugg

International Classification:

C12Q 1/00
C12M 1/00

US Classification:

422119000, 422050000, 435289100

Abstract:

The invention relates to a device for automated bioreactor sampling connected to a reactor comprising a sampler, at least one tube fluidly connecting said reactor with said sampler and a pump for pumping fluids from said reactor to said sampler and vice versa. Particularly simple and essentially dead volume-free sampling can be achieved by providing means for flushing at least parts of the tube with gas/sterile air between individual sampling steps. The invention furthermore relates to a method of operation of such a device.