Christopher N Carlson

US Patent:

7791466, Sep 7, 2010

Filed:

Jan 11, 2008

Appl. No.:

11/972765

Inventors:

Lalit Agarwalla - Bangalore, IN
Sergio Borger - Paramus NJ, US
Lisa M. Brown - Pleasantville NY, US
Christopher R. Carlson - Costa Mesa CA, US
Raymond A. Cooke - Bloomington MN, US
Barry Gottlieb - Short Hills NJ, US
Arun Hampapur - Norwalk CT, US
Christopher A. LoGiudice - Bethel CT, US
Linda C. Owen - Counce TN, US
Andrew W. Senior - New York NY, US
Chiao-Fe Shu - Scarsdale NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G08B 23/00

US Classification:

340517, 340506, 340 31, 34082536, 34082549

Abstract:

The present invention includes a method, system, and program product for detecting an event that includes receiving at least one data input stream from one or more sensors, selecting a data input stream from one of the one or more sensors, recording the data input stream on a recordable medium, specifying a rule comprising an event in the data input stream, and detecting at least one event in the data input stream based upon the rule.

US Patent:

8642750, Feb 4, 2014

Filed:

Jun 4, 2010

Appl. No.:

12/794507

Inventors:

Harlan S. Robins - Seattle WA, US
Christopher Scott Carlson - Kirkland WA, US

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

C07H 21/04

US Classification:

536 243

Abstract:

A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.

US Patent:

20080232641, Sep 25, 2008

Filed:

Mar 20, 2007

Appl. No.:

11/688281

Inventors:

Sergio Borger - Demarest NJ, US
Christopher R. Carlson - Incline Village NV, US
Arun Hampapur - Norwalk CT, US
Andrew W. Senior - New York NY, US
Chiao-Fe Shu - Scarsdale NY, US

International Classification:

G06K 9/00

US Classification:

382103, 382100

Abstract:

The present invention relates to the measurement of human activities through video, particularly in retail environments. A method for measuring retail display effectiveness in accordance with an embodiment of the present invention includes: detecting a moving object in a field of view of an imaging device, the imaging device obtaining image data of a product display; tracking the object in the field of view of the imaging device to obtain a track; and obtaining statistics for the track with regard to the product display.

US Patent:

20120058902, Mar 8, 2012

Filed:

Aug 24, 2011

Appl. No.:

13/217126

Inventors:

Robert J. Livingston - Seattle WA, US
Christopher S. Carlson - Kirkland WA, US
Harlan S. Robins - Seattle WA, US

International Classification:

C40B 30/00
C40B 40/06

US Classification:

506 7, 506 16

Abstract:

Compositions and methods for measuring adaptive immune receptor (T cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. Lymphoid (B- and T-cell) adaptive immune receptor diversity is quantified by calculating the number of uniquely rearranged, CDR3-containing immunoglobulin (Ig) or T-cell receptor (TCR) variable region-encoding genes from sample cells such as blood cells.

US Patent:

20210381050, Dec 9, 2021

Filed:

Jun 9, 2021

Appl. No.:

17/343552

Inventors:

- Seattle WA, US
Mark J. Rieder - Seattle WA, US
Christopher S. Carlson - Seattle WA, US

International Classification:

C12Q 1/6881
C12Q 1/68
C12Q 1/70
C12Q 1/6883

Abstract:

Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences. The methods of the present invention may be used to predict the status of several infectious agents in a single sample from a subject. Methods are also provided for predicting a subject's HLA status using high-throughput immune receptor sequencing.

US Patent:

20190203281, Jul 4, 2019

Filed:

Jan 8, 2019

Appl. No.:

16/242109

Inventors:

- Seattle WA, US
Christopher Scott CARLSON - Seattle WA, US
Robert J. LIVINGSTON - Seattle WA, US
Ryan O. EMERSON - Seattle WA, US
Anna M. SHERWOOD - Seattle WA, US

International Classification:

C12Q 1/6851
C12Q 1/6806
C12Q 1/6881

Abstract:

Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG). The presently disclosed embodiments are useful to overcome undesirable bias in the utilization of a subset of amplification primers, which leads to imprecision in multiplexed high throughput sequencing of amplification products to quantify unique TCR or Ig encoding genomes in a sample. Provided is a template composition comprising a diverse plurality of template oligonucleotides in substantially equimolar amounts, for use as a calibration standard for amplification primer sets. Also provided are methods for identifying and correcting biased primer efficiency during amplification.

US Patent:

20180312832, Nov 1, 2018

Filed:

Jun 29, 2018

Appl. No.:

16/023010

Inventors:

- SEATTLE WA, US
Christopher Scott CARLSON - Kirkland WA, US

International Classification:

C12N 15/10
G06F 19/24
C12Q 1/6881
C12Q 1/6869
C12Q 1/6883
C12Q 1/6874

Abstract:

A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.

US Patent:

20180073015, Mar 15, 2018

Filed:

Sep 20, 2017

Appl. No.:

15/709719

Inventors:

- Seattle WA, US
Christopher Scott Carlson - Kirkland WA, US

International Classification:

C12N 15/10
G06F 19/24
C12Q 1/68

Abstract:

A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.

Address:

2800 W 44 St UNIT 409, Minneapolis, MN 55410

VIN:

WBAPH7C53BE126041

Make:

BMW

Model:

3 SERIES

Year:

2011

Address:

6908 W 82 St, Minneapolis, MN 55438

VIN:

3VWGF71K67M049746

Make:

VOLKSWAGEN

Model:

JETTA

Year:

2007