Christopher Andrew Cottrell

US Patent:

20200061185, Feb 27, 2020

Filed:

Oct 25, 2017

Appl. No.:

16/344774

Inventors:

- Bethesda MD, US
- La Jolla CA, US
- Hanover NH, US
Robert Kirchdoerfer - La Jolla CA, US
Christopher Cottrell - La Jolla CA, US
Michael Gordon Joyce - Washington DC, US
Masaru Kanekiyo - Chevy Chase MD, US
Jesper Pallesen - La Jolla CA, US
Hadi Yassine - Doha, QA
Hannah Turner - La Jolla CA, US
Kizzmekia Corbett - Bethesda MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Servic - Bethesda MD
The Scripps Research Institute - La Jolla CA
Trustees of Dartmouth College - Hanover NH

International Classification:

A61K 39/215
C07K 14/005
A61P 31/14
C12N 7/00

Abstract:

Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.