In situ Raman spectroscopy methods and systems for characterizing or quantifying a protein purification intermediate and/or final concentrated pool during production or manufacture are provided. In one embodiment, in situ Raman spectroscopy is used to characterize or quantify protein purification intermediates critical quality attributes during downstream processing (i.e., after harvest of the protein purification intermediate). For example, the disclosed in situ Raman spectroscopy methods and systems can be used to characterize and quantify protein purification intermediates as the protein purification intermediates are purified, condensed, or otherwise formulated into the final drug product to be sold or administered.
Use Of Raman Spectroscopy In Downstream Purification
In situ Raman spectroscopy methods and systems for characterizing or quantifying a protein purification intermediate and/or final concentrated pool during production or manufacture are provided. In one embodiment, in situ Raman spectroscopy is used to characterize or quantify protein purification intermediates critical quality attributes during downstream processing (i.e., after harvest of the protein purification intermediate). For example, the disclosed in situ Raman spectroscopy methods and systems can be used to characterize and quantify protein purification intermediates as the protein purification intermediates are purified, condensed, or otherwise formulated into the final drug product to be sold or administered
Regeneron Pharmaceuticals - Tarrytown, NY since Dec 2010
Staff Engineer
Regeneron Pharmaceuticals - Tarrytown, NY Jul 2008 - Nov 2010
Research Engineer
UMBC 2003 - 2008
Research Assistant
Education:
University of Maryland Baltimore County 2003 - 2008
Ph.D., Chemical & Biochemical Engineering
University of Maryland Baltimore County 2003 - 2005
Masters, Chemical & Biochemical Engineering
Penn State University 1999 - 2003
B.S., Chemical Engineering
Skills:
Chromatography Chemical Engineering Technology Transfer Affinity Chromatography Mathematical Modeling Nanofiltration Tangential Flow Filtration Sterile Filtration Subvisible Particles
INTERNATIONAL BUSINESS MACHINES (IBM) / Global Business Services (GBS)
Jun 2001 to Present Strategy and Transformation - Managing ConsultantINTERNATIONAL BUSINESS MACHINES (IBM) / IBM Marketing Philadelphia, PA Aug 2010 to Dec 2011 Marketing Development Analyst Competitive IntelligenceFREEDOMPAY.COM Wayne, PA Dec 2000 to Jun 2001 Program/Project ManagerWINEACCESS.COM Narberth, PA Dec 1999 to Nov 2000 Deployment/Project ManagerSOUTHERN WINE & SPIRITS INC Valley Forge, PA Feb 1998 to Nov 1999 IS/IT ManagerPharmaceutical Marketing Company Fort Washington, PA Mar 1996 to Jan 1998 Management Trainee and IT/Data Analyst
Education:
Temple University 2001 MBA in Management Information SystemsUniversity of Pittsburgh 1996 BA in Business & Communications
Skills:
IT Strategy Supply Chain Strategy/PlanningInventory OptimizationMerchandising POS & ERP Systems/Selection Process IT HW/SW Integration Price OptimizationConsumer Demand ManagementProject ManagementCompetitive IntelligenceField IntelligenceMarketing Development
The research team includedMakoto Taniguchi, Ph.D., assistant professor in the Department of Neuroscience,Christopher Cowan, Ph.D., professor and chair of the Department of Neuroscience, and Rose Marie Akiki, an M.D.-Ph.D. student at MUSC.
Date: Dec 13, 2024
Category: Health
Source: Google
A New Epigenetic Brain Defense Against Recurrence of Opioid Use
Individuals make long-lasting associations between the euphoric experience of the drug and the people, places and things associated with drug use, said Christopher Cowan, Ph.D. professor in the Department of Neuroscience at the Medical University of South Carolina (MUSC) and member of the Brain an